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Table 5 Area under the ROC curve (AUC) calculations for efficacy prediction of the biomarkers

From: Biomarkers can predict potential clinical responders to DIMS0150 a toll-like receptor 9 agonist in ulcerative colitis patients

   CD163 TSP1 IL-6 CD163/TSP-1/IL-6
Steroid response Dex 10-8 0.86 0.88 0.60 0.91
  Dex 10-6 0.85 0.87 0.83 0.91
Steroid enhancement Dex 10-8 0.82 0.80 N/A# 0.86*
  Dex 10-6 0.77 0.81 N/A# 0.96*
Steroid response and enhancement Dex 10-6 - - - 0.98
  1. #Not applicable as the level of repression of DIMS0150 induced expression of IL-6 is analyzed.
  2. *Calculation was performed including steroid response data of IL-6.
  3. Bold number indicates highest efficacy prediction.