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Table 5 Area under the ROC curve (AUC) calculations for efficacy prediction of the biomarkers

From: Biomarkers can predict potential clinical responders to DIMS0150 a toll-like receptor 9 agonist in ulcerative colitis patients

  

CD163

TSP1

IL-6

CD163/TSP-1/IL-6

Steroid response

Dex 10-8

0.86

0.88

0.60

0.91

 

Dex 10-6

0.85

0.87

0.83

0.91

Steroid enhancement

Dex 10-8

0.82

0.80

N/A#

0.86*

 

Dex 10-6

0.77

0.81

N/A#

0.96*

Steroid response and enhancement

Dex 10-6

-

-

-

0.98

  1. #Not applicable as the level of repression of DIMS0150 induced expression of IL-6 is analyzed.
  2. *Calculation was performed including steroid response data of IL-6.
  3. Bold number indicates highest efficacy prediction.