Figure 7

Biomarker assay confirms restoration of steroid sensitivity. A chronic active treatment refractory UC patient was treated on a named patient basis with three doses of DIMS0150 with four weeks between dosing. Whole blood was collected prior to first dose and four weeks following last dose (week 12) and PBMC incubated for 48 hrs in the absence or presence of Dexamethasone and/or DIMS0150. Following incubation mRNA levels of IL-6 (A), CD163 (B) and TSP-1 (C) were analysed.