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Table 3 Frequency of KRAS mutations and types of alterations according to gender

From: KRAS mutations: variable incidences in a Brazilian cohort of 8,234 metastatic colorectal cancer patients

KRAS mutation type Female n (%) Male n (%) Total mutation n (%)
1,305 (100) 1,318 (100) 2,623 (100)
Codon 12 1,082 (83) 1,093 (83) 2,175 (83)
Gly12Asp (GGT > GAT) 457 (35) 498 (37.8) 955 (36.4)
Gly12Val (GGT > GTT) 312 (23.9) 325 (24.7) 637 (24.3)
Gly12Ser (GGT > AGT) 102 (7.8) 92 (7) 194 (7.4)
Gly12Ala (GGT > GCT) 78 (6) 71 (5.4) 149 (57)
Gly12Cys (GGT > TGT) 112 (8.6) 94 (7.1) 206 (7.9)
Gly12Arg (GGT > CGT) 21 (1.6) 13 (1) 34 (1.3)
Codon 13 223 (17) 224 (17) 447 (17)
Gly13Asp (GGC > GAC) 215 (16.5) 208 (15.8) 423 (16.1)
Gly13Cys (GGC > TGC) 3 (0.2) 10 (0.8) 13 (0.5)
Gly13Ser (GGC > AGC) 3 (0.2) 3 (0.2) 6 (0.2)
Gly13Val (GGC > GTT) 1 (0.1) 1 (0.1) 2 (0.1)
Gly13Arg (GGC > CGC) 1 (0.1) 2 (0.2) 3 (0.1)
Gly12Ser (GGT > TTT)* - - 1
  1. *Missing data.
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