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Table 1 Cytokine levels in mucosal tissue

From: Mucosal gene therapy using a pseudotyped lentivirus vector encoding murine interleukin-10 (mIL-10) suppresses the development and relapse of experimental murine colitis

Cytokine

DSS day

NC

Mock

LV(1)

LV(2)

IL-10

10

ND

3.9 ± 1.6

18.1 ± 3.9*

15.9 ± 3.7*

32

ND

ND

12.9 ± 12.1

14.3 ± 0.7

TNF-α

10

0.7 ± 0.3

25.4 ± 9.4

11.5 ± 5.4

3.9 ± 1.8

32

0.6 ± 0.4

15.2 ± 6.5

3.5 ± 1.4*

3.9 ± 2.9

IL-6

10

ND

ND

ND

ND

 

32

ND

14.5 ± 1.3

ND

ND

  1. *p <0.05 compared to mock infection.
  2. ND; Not detected.