Figure 5

Histopathology sections of DSS colitis treated with LV encoding mIL-10. Representative sections of each treatment groups are shown following DSS exposure at Day 10 (a, b, c, d) or Day 32 (e, f, g, h). Normal controls for each are shown in (a) and (e). Mock-treatment group showed the expected severe colonic inflammation on both Days 10 and 32. Treatment with LV encoding mIL-10, regardless of whether given once per DSS cycle (LV(1)) or twice/cycle (LF(2)), showed reduction in inflammation on both Days 10 and 32. (H & E stain; magnification: 200×).