Effect of treatment with anti-HMGB1 antibody or sham IgG on gut mucosal permeability in mice with acetaminophen overdose. Ileal mucosal permeability was assessed 24 and 48 hrs after acetaminophen administration. The animal model and treatment were the same as described in Figure 1. Results are means ± SEM. *indicates p < 0.05 (student’s T test).