Effect of treatment with anti-HMGB1 antibody or sham IgG on bacterial translocation in mice with acetaminophen overdose. A: Bacterial translocation (BT) to mesenteric lymph nodes (MLN) was assessed 24 and 48 hrs after APAP injection. B: Bacterial translocation to the liver was assessed 24 and 48 hrs after APAP injection. The animal model and treatment were the same as described in Figure 1. Results are means ± SEM. *indicates p < 0.05 (Wilcoxon U-test).