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Table 3 Predictive values and Area under the ROC curve (AUROC) of sustained virological response based on a log 10 decrease in total HCV core antigen and HCV RNA concentrations after initial antiviral treatment

From: Hepatitis C virus core antigen, an earlier and stronger predictor on sustained virological response in patients with genotype 1 HCV infection

 

PPV

NPV

AUROC (95% CI)

∆HCVcAg (log10 fmol/L)

   

144 h

100%

76.9%

0.913 (0.799-1.000)

Week 4

100%

68.7%

0.853 (0.720-0.985)

Week 8

100%

61.1%

0.823 (0.680-0.965)

Week 12

100%

68.7%

0.719 (0.520-0.917)

∆HCV RNA (log10 IU/mL)

   

Week 4

100%

70.6%

0.854 (0.705-1.000)

  1. PPV, positive predictive value; NPV, negative predictive value; AUROC, areas under the univariate receiver operating characteristic curve.
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BMC Gastroenterology

ISSN: 1471-230X

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