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Table 3 Predictive values and Area under the ROC curve (AUROC) of sustained virological response based on a log 10 decrease in total HCV core antigen and HCV RNA concentrations after initial antiviral treatment

From: Hepatitis C virus core antigen, an earlier and stronger predictor on sustained virological response in patients with genotype 1 HCV infection

  PPV NPV AUROC (95% CI)
∆HCVcAg (log10 fmol/L)    
144 h 100% 76.9% 0.913 (0.799-1.000)
Week 4 100% 68.7% 0.853 (0.720-0.985)
Week 8 100% 61.1% 0.823 (0.680-0.965)
Week 12 100% 68.7% 0.719 (0.520-0.917)
∆HCV RNA (log10 IU/mL)    
Week 4 100% 70.6% 0.854 (0.705-1.000)
  1. PPV, positive predictive value; NPV, negative predictive value; AUROC, areas under the univariate receiver operating characteristic curve.