Confocal laser endomicroscopy (CLE) crypt architecture (A, C, E and G) and conventional histology (B, D, F and H). A and B: CLE image and histology of normal colonic mucosa show regular-shaped and distributed crypts. C and D: CLE image and histology of chronic inflammation of colonic mucosa show irregular-shaped, distributed but intact crypts. E and F: CLE image and histology show more dilated crypts with fluorescein leakage into the lumen, with the epithelium disrupted in some crypts. G and H: CLE image and histology show most of the crypts are disrupted.