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Table 1 Demographical characteristics of the study population

From: Management of the HBV reactivation in isolated HBcAb positive patients affected with Non Hodgkin Lymphoma

Variable

Overall

HBsAg positive

HBsAg negative

p

No. of patients

498

38

460

-

Age - Mean [±SD]

61,00 [±14,05]

55,42 [±13,62]

57,32 [±14,95]

0,45

Sex – M/F

M: 54,40% -

M: 57,89%

M: 47,83%

0,23

F: 45,40%

F: 42,11%

F: 52,17%

No. of patients HBsAb +

90 [18,07%]

0

90 [19,56%]

0,003

No. of patients HBcAb +/ HBsAg -

134 [26,90%]

0

96 [20,86%]

0,002

No. of patients HBcAb - / HBsAg -

274 [55,03%]

0

274 [59,56%]

 

Lymphoma type

Indolent: 47,3% -

Indolent: 33,35% -

Indolent: 44,34% -

0,22

 

Aggressive: 52,7%

Aggressive: 66,65%

Aggressive: 55,66%

0,22

Rituximab therapy

Yes: 60,30% -

Yes: 18 [47,37%]

Yes 262 [56,95%]

0,25

No: 39,70%

No: 20 [52,63%]

No: 198 [43,04%]

 

HBV reactivation

10 [2,01%]

0

10 [2,17%]

0,22

NUC profilaxys/rescue therapy

38/10

38/0

0/10

<0,0001

“Per year Incidence of reactivation” [mean ± SD]

1,71%

0

2,04%

<0,0001

±2,43%

±2,97

Liver related decompensations/hospitalizations/deaths

0%

0%

0%

-

  1. In the first column overall patients characteristics: HBV reactivation occurred in 2,01% of cases. In the second and third column demographical characteristics of HBsAg positive and negative patients, respectively. HBV reactivation occurred in HBsAg negative patients only, due to the NUC profilaxys performed in HBsAg positive patients [see Methods]. (Chi-square, Pearson corrected calculations for all variables, Age: student t-test).