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Table 3 Comparison of the clinical characteristics of chronic hepatitis C patients with (F2–3) or without (F0–1) advanced hepatic fibrosis

From: Serum levels of apoptosis inhibitor of macrophage are associated with hepatic fibrosis in patients with chronic hepatitis C

  

F0 – F1

  

F2 – F3

  

(n = 36)

(n = 41)

Factor

Mean or number

Maximum

Minimum

Mean or number

Maximum

Minimum

Pvalue*

Age (years)

53

71

22

59

76

20

0.029

Sex (male/female)

14/22

  

17/24

  

0.818

Body mass index (kg/m2)

23.2

30.1

16.4

23.6

32.2

17.8

0.814

HCV serotype (I/II)

21/15

  

26/15

  

0.815

Viral load (log IU/ml)

6

7.3

2.7

5.8

7.3

2.4

0.606

Platelet count (×104/μl)

21

41.9

9.8

15.5

39.7

5.4

<0.001

Total cholesterol (mg/dl)

179.4

295

84

163

251

92

0.071

Albumin (g/dl)

4.5

5.1

3.5

4.1

4.9

2.9

<0.001

ALT (IU/L)

40.3

181

13

85.8

244

17

<0.001

γ-GTP (IU/L)

31.7

114

12

66.3

468

12

0.001

Diabetes (absent/present)

6/30

  

11/30

  

0.283

Fasting plasma glucose (mg/dl)

95.3

155

75

98.6

196

72

0.810

Hemoglobin A1c (%)

5.3 (n = 35)

6.7

4.6

5.5 (n = 40)

7.6

4.6

0.861

Leptin (ng/ml)

6.9

21.8

1.0

8.2

21.3

1.1

0.086

Adiponectin (ng/ml)

8.8

27.3

1.7

9.1

26.7

1.1

0.653

Resistin (ng/ml)

8.1

27.6

2.5

8.9

17.8

3

0.156

AIM (μg/ml)

1.06

2.02

0.41

1.68

6.44

0.76

<0.001

Hyaluronic acid (ng/ml)

42.6

10.0

292.7

145.0 (n = 39)

10.0

636.0

<0.001

  1. *Calculated by Chi-square test for categorical variables or Mann–Whitney U test for continuous variables.
  2. ALT, alanine aminotransferase; γ-GTP, γ-glutamyl transpeptidase; HOMA-IR, homeostasis model assessment-insulin resistance; AIM, apoptosis inhibitor of macrophage.
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BMC Gastroenterology

ISSN: 1471-230X

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