Skip to main content

Advertisement

Table 3 Comparison of the clinical characteristics of chronic hepatitis C patients with (F2–3) or without (F0–1) advanced hepatic fibrosis

From: Serum levels of apoptosis inhibitor of macrophage are associated with hepatic fibrosis in patients with chronic hepatitis C

   F0 – F1    F2 – F3   
(n = 36) (n = 41)
Factor Mean or number Maximum Minimum Mean or number Maximum Minimum Pvalue*
Age (years) 53 71 22 59 76 20 0.029
Sex (male/female) 14/22    17/24    0.818
Body mass index (kg/m2) 23.2 30.1 16.4 23.6 32.2 17.8 0.814
HCV serotype (I/II) 21/15    26/15    0.815
Viral load (log IU/ml) 6 7.3 2.7 5.8 7.3 2.4 0.606
Platelet count (×104/μl) 21 41.9 9.8 15.5 39.7 5.4 <0.001
Total cholesterol (mg/dl) 179.4 295 84 163 251 92 0.071
Albumin (g/dl) 4.5 5.1 3.5 4.1 4.9 2.9 <0.001
ALT (IU/L) 40.3 181 13 85.8 244 17 <0.001
γ-GTP (IU/L) 31.7 114 12 66.3 468 12 0.001
Diabetes (absent/present) 6/30    11/30    0.283
Fasting plasma glucose (mg/dl) 95.3 155 75 98.6 196 72 0.810
Hemoglobin A1c (%) 5.3 (n = 35) 6.7 4.6 5.5 (n = 40) 7.6 4.6 0.861
Leptin (ng/ml) 6.9 21.8 1.0 8.2 21.3 1.1 0.086
Adiponectin (ng/ml) 8.8 27.3 1.7 9.1 26.7 1.1 0.653
Resistin (ng/ml) 8.1 27.6 2.5 8.9 17.8 3 0.156
AIM (μg/ml) 1.06 2.02 0.41 1.68 6.44 0.76 <0.001
Hyaluronic acid (ng/ml) 42.6 10.0 292.7 145.0 (n = 39) 10.0 636.0 <0.001
  1. *Calculated by Chi-square test for categorical variables or Mann–Whitney U test for continuous variables.
  2. ALT, alanine aminotransferase; γ-GTP, γ-glutamyl transpeptidase; HOMA-IR, homeostasis model assessment-insulin resistance; AIM, apoptosis inhibitor of macrophage.