A randomized, double-blind, placebo-controlled, multiple-dose, parallel-group clinical trial to assess the effects of teduglutide on gastric emptying of liquids in healthy subjects

Table 3 **Acetaminophen pharmacokinetic parameters on day 10 (PK/PD population*)**

Pharmacokinetic parameter, mean ± SD	Placebo (n = 12)	Teduglutide 4 mg (n = 23)	Pvalue
AUC_0–last, ng∙hour/mL	47,652 ± 9377	60,984 ± 15,710	0.32
AUC_0–inf, ng∙hour/mL	50,036 ± 9706	65,279 ± 17,039	0.26
C_max, ng/mL	10,679 ± 2246	12,677 ± 3821	0.28
t_max, hour	1.5	1.7	0.65

AUC = area under the curve; AUC_0–last = AUC from time 0 to the last measurable concentration; AUC_0–inf = AUC from time 0 extrapolated to infinity; C_max = maximum plasma concentration; PD = pharmacodynamic; PK = pharmacokinetic; t_max = time to C_max.
*1 patient in the placebo group withdrew consent on Day 7 and therefore did not have PK/PD data for Day 10.

ISSN: 1471-230X