Skip to main content

Table 3 Acetaminophen pharmacokinetic parameters on day 10 (PK/PD population*)

From: A randomized, double-blind, placebo-controlled, multiple-dose, parallel-group clinical trial to assess the effects of teduglutide on gastric emptying of liquids in healthy subjects

Pharmacokinetic parameter, mean ± SD Placebo (n = 12) Teduglutide 4 mg (n = 23) Pvalue
AUC0–last, ng∙hour/mL 47,652 ± 9377 60,984 ± 15,710 0.32
AUC0–inf, ng∙hour/mL 50,036 ± 9706 65,279 ± 17,039 0.26
Cmax, ng/mL 10,679 ± 2246 12,677 ± 3821 0.28
tmax, hour 1.5 1.7 0.65
  1. AUC = area under the curve; AUC0–last = AUC from time 0 to the last measurable concentration; AUC0–inf = AUC from time 0 extrapolated to infinity; Cmax = maximum plasma concentration; PD = pharmacodynamic; PK = pharmacokinetic; tmax = time to Cmax.
  2. *1 patient in the placebo group withdrew consent on Day 7 and therefore did not have PK/PD data for Day 10.