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Table 2 Meta-analyses of the association between the 5-HTTLPR polymorphism and the presence of IBS

From: The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies

 

Ethnicity

Cases/Controls

L vs S

  

LL vs SS

  

LL vs LS

  
   

(OR,95% CI)

P (Model)

Bon

(OR,95% CI)

P (Model)

Bon

(OR,95% CI)

P (Model)

Bon

IBS

           

 25 studies

Overall

3443/3359

(0.993,0.867-1.138)

P = 0.923 (R)

1.000

(1.009,0.772-1.319)

P = 0.948 (R)

1.000

(1.284,1.040-1.585)

P = 0.020 (R)

0.120

 11 studies

Cau/M Cau

1855/1590

(1.008,0.859-1.183)

P = 0.919 (R)

1.000

(1.018,0.752-1.378)

P = 0.907 (R)

1.000

(1.288,1.079-1.536)

P = 0.005 (F)

0.030

 9 studies

East Asian

1138/1102

(1.151,0.901-1.471)

P = 0.261 (R)

1.000

(1.371,0.764-2.461)

P = 0.291 (R)

1.000

(1.528,0.849-2.751)

P = 0.157 (R)

0.942

 1 study

Turkish

54/92

(0.934,0.577-1.514)

P = 0.782

1.000

(0.727,0.271-1.952)

P = 0.527

1.000

(0.442,0.171-1.143)

P = 0.092

0.552

 2 studies

Indian

301/352

(0.687,0.375-1.259)

P = 0.225 (R)

1.000

(0.588,0.241-1.435)

P = 0.243 (R)

1.000

(1.077,0.669-1.733)

P = 0.761 (F)

1.000

 1 study

Mexian

45/123

(0.482,0.256-0.910)

P = 0.024

0.144

(0.290,0.082-1.030)

P = 0.056

0.336

(0.313,0.073-1.337)

P = 0.117

0.702

 1 study

Iranian

50/100

(1.083,0.670-1.751)

P = 0.744

1.000

(1.168,0.466-2.931)

P = 0.740

1.000

(2.246,0.976-5.165)

P = 0.057

1.000

IBS-C

           

 20 studies

Overall

992/2437

(1.232,1.048-1.449)

P = 0.011 (R)

0.066

(1.570,1.147-2.148)

P = 0.005 (F)

0.030

(1.658,1.180-2.331)

P = 0.004 (R)

0.024

 8 studies

Cau/M Cau

462/841

(1.270,1.060-1.520)

P = 0.009 (F)

0.054

(1.627,1.109-2.388)

P = 0.013 (F)

0.078

(1.269,0.956-1.685)

P = 0.100 (F)

1.000

 8 studies

East Asian

393/1052

(1.487,1.139-1.941)

P = 0.003 (R)

0.018

(2.575,1.741-3.808)

P = 0.000 (F)

0.000

(3.084,2.017-4.715)

P = 0.000 (F)

0.000

 1 study

Turkish

26/92

(0.719,0.379-1.367)

P = 0.315

1.000

(0.545,0.156-1.903)

P = 0.342

1.000

(0.618,0.172-2.218)

P = 0.461

1.000

 2 studies

Indian

96/352

(0.798,0.438-1.452)

P = 0.460 (R)

1.000

(0.676,0.330-1.384)

P = 0.284 (F)

1.000

(0.769,0.389-1.522)

P = 0.451 (F)

1.000

 1 study

Iranian

15/100

(0.796,0.367-1.725)

P = 0.563

1.000

(0.730,0.181-2.951)

P = 0.659

1.000

(2.133,0.522-8.714)

P = 0.291

1.000

 IBS-D

           

 21 studies

Overall

1454/2813

(0.932,0.771-1.126)

P = 0.466 (R)

1.000

(0.888,0.666-1.183)

P = 0.416 (R)

1.000

(1.209,0.973-1.502)

P = 0.086 (R)

0.516

 9 studies

Cau/M Cau

806/1270

(0.986,0.863-1.126)

P = 0.835 (F)

1.000

(0.921,0.706-1.200)

P = 0.540 (F)

1.000

(1.251,1.005-1.556)

P = 0.045 (F)

0.270

 8 studies

East Asian

434/999

(0.846,0.694-1.032)

P = 0.099 (F)

0.594

(0.785,0.498-1.239)

P = 0.299 (F)

1.000

(0.930,0.579-1.494)

P = 0.764 (F)

1.000

 1 study

Turkish

18/92

(1.087,0.529-2.232)

P = 0.820

1.000

(0.324,0.015-7.070)

P = 0.474

1.000

(0.046,0.003-0.814)

P = 0.036

0.216

 2 studies

Indian

171/352

(0.478,0.084-2.707)

P = 0.404 (R)

0.828

(0.494,0.069-3.514)

P = 0.481 (R)

1.000

(1.355,0.715-2.566)

P = 0.351 (F)

1.000

 1 study

Iranian

25/100

(1.325,0.710-2.471)

P = 0.377

1.000

(1.565,0.504-4.856)

P = 0.439

1.000

(3.333,1.159-9.586)

P = 0.025

0.150

IBS-M

           

 17 studies

Overall

486/2042

(1.087,0.911-1.296)

P = 0.354 (R)

1.000

(1.170,0.830-1.651)

P = 0.370 (R)

1.000

(1.313,0.991-1.740)

P = 0.058 (F)

0.348

 6 studies

Cau/M Cau

265/549

(1.096,0.754-1.593)

P = 0.630 (R)

1.000

(1.153,0.538-2.471)

P = 0.714 (R)

1.000

(1.533,1.069-2.198)

P = 0.020 (F)

0.120

 7 studies

East Asian

167/949

(1.030,0.785-1.351)

P = 0.830 (F)

1.000

(1.135,0.637-2.022)

P = 0.667 (F)

1.000

(0.906,0.507-1.617)

P = 0.737 (F)

1.000

 1 study

Turkish

10/92

(2.038,0.795-5.225)

P = 0.138

0.828

(4.909,0.480-50.178)

P = 0.180

1.000

(0.773,0.175-3.415

P = 0.734

1.000

 2 studies

Indian

34/352

(1.022,0.616-1.697)

P = 0.932 (F)

1.000

(1.157,0.452-2.965)

P = 0.761 (F)

1.000

(1.684,0.662-4.280

P = 0.274 (F)

1.000

 1 study

Iranian

10/100

(1.041,0.415-2.610)

P = 0.932

1.000

(1.095,0.141-8.485)

P = 0.931

1.000

(0.889,0.166-4.755

P = 0.891

1.000

  1. Cau/M Cau: Caucasian/Mostly Caucasian; F: fixed model; R: random model; Bon: P for Bonferroni adjustment. The significant contrasts were written in bold.