| Ethnicity | Cases/Controls | L vs S |  |  | LL vs SS |  |  | LL vs LS |  |  |
---|---|---|---|---|---|---|---|---|---|---|---|
 |  |  | (OR,95% CI) | P (Model) | Bon | (OR,95% CI) | P (Model) | Bon | (OR,95% CI) | P (Model) | Bon |
IBS | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 25 studies | Overall | 3443/3359 | (0.993,0.867-1.138) | P = 0.923 (R) | 1.000 | (1.009,0.772-1.319) | P = 0.948 (R) | 1.000 | (1.284,1.040-1.585) | P = 0.020 (R) | 0.120 |
 11 studies | Cau/M Cau | 1855/1590 | (1.008,0.859-1.183) | P = 0.919 (R) | 1.000 | (1.018,0.752-1.378) | P = 0.907 (R) | 1.000 | (1.288,1.079-1.536) | P = 0.005 (F) | 0.030 |
 9 studies | East Asian | 1138/1102 | (1.151,0.901-1.471) | P = 0.261 (R) | 1.000 | (1.371,0.764-2.461) | P = 0.291 (R) | 1.000 | (1.528,0.849-2.751) | P = 0.157 (R) | 0.942 |
 1 study | Turkish | 54/92 | (0.934,0.577-1.514) | P = 0.782 | 1.000 | (0.727,0.271-1.952) | P = 0.527 | 1.000 | (0.442,0.171-1.143) | P = 0.092 | 0.552 |
 2 studies | Indian | 301/352 | (0.687,0.375-1.259) | P = 0.225 (R) | 1.000 | (0.588,0.241-1.435) | P = 0.243 (R) | 1.000 | (1.077,0.669-1.733) | P = 0.761 (F) | 1.000 |
 1 study | Mexian | 45/123 | (0.482,0.256-0.910) | P = 0.024 | 0.144 | (0.290,0.082-1.030) | P = 0.056 | 0.336 | (0.313,0.073-1.337) | P = 0.117 | 0.702 |
 1 study | Iranian | 50/100 | (1.083,0.670-1.751) | P = 0.744 | 1.000 | (1.168,0.466-2.931) | P = 0.740 | 1.000 | (2.246,0.976-5.165) | P = 0.057 | 1.000 |
IBS-C | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 20 studies | Overall | 992/2437 | (1.232,1.048-1.449) | P = 0.011 (R) | 0.066 | (1.570,1.147-2.148) | P = 0.005 (F) | 0.030 | (1.658,1.180-2.331) | P = 0.004 (R) | 0.024 |
 8 studies | Cau/M Cau | 462/841 | (1.270,1.060-1.520) | P = 0.009 (F) | 0.054 | (1.627,1.109-2.388) | P = 0.013 (F) | 0.078 | (1.269,0.956-1.685) | P = 0.100 (F) | 1.000 |
 8 studies | East Asian | 393/1052 | (1.487,1.139-1.941) | P = 0.003 (R) | 0.018 | (2.575,1.741-3.808) | P = 0.000 (F) | 0.000 | (3.084,2.017-4.715) | P = 0.000 (F) | 0.000 |
 1 study | Turkish | 26/92 | (0.719,0.379-1.367) | P = 0.315 | 1.000 | (0.545,0.156-1.903) | P = 0.342 | 1.000 | (0.618,0.172-2.218) | P = 0.461 | 1.000 |
 2 studies | Indian | 96/352 | (0.798,0.438-1.452) | P = 0.460 (R) | 1.000 | (0.676,0.330-1.384) | P = 0.284 (F) | 1.000 | (0.769,0.389-1.522) | P = 0.451 (F) | 1.000 |
 1 study | Iranian | 15/100 | (0.796,0.367-1.725) | P = 0.563 | 1.000 | (0.730,0.181-2.951) | P = 0.659 | 1.000 | (2.133,0.522-8.714) | P = 0.291 | 1.000 |
 IBS-D |  |  |  |  |  |  |  |  |  |  |  |
 21 studies | Overall | 1454/2813 | (0.932,0.771-1.126) | P = 0.466 (R) | 1.000 | (0.888,0.666-1.183) | P = 0.416 (R) | 1.000 | (1.209,0.973-1.502) | P = 0.086 (R) | 0.516 |
 9 studies | Cau/M Cau | 806/1270 | (0.986,0.863-1.126) | P = 0.835 (F) | 1.000 | (0.921,0.706-1.200) | P = 0.540 (F) | 1.000 | (1.251,1.005-1.556) | P = 0.045 (F) | 0.270 |
 8 studies | East Asian | 434/999 | (0.846,0.694-1.032) | P = 0.099 (F) | 0.594 | (0.785,0.498-1.239) | P = 0.299 (F) | 1.000 | (0.930,0.579-1.494) | P = 0.764 (F) | 1.000 |
 1 study | Turkish | 18/92 | (1.087,0.529-2.232) | P = 0.820 | 1.000 | (0.324,0.015-7.070) | P = 0.474 | 1.000 | (0.046,0.003-0.814) | P = 0.036 | 0.216 |
 2 studies | Indian | 171/352 | (0.478,0.084-2.707) | P = 0.404 (R) | 0.828 | (0.494,0.069-3.514) | P = 0.481 (R) | 1.000 | (1.355,0.715-2.566) | P = 0.351 (F) | 1.000 |
 1 study | Iranian | 25/100 | (1.325,0.710-2.471) | P = 0.377 | 1.000 | (1.565,0.504-4.856) | P = 0.439 | 1.000 | (3.333,1.159-9.586) | P = 0.025 | 0.150 |
IBS-M | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 17 studies | Overall | 486/2042 | (1.087,0.911-1.296) | P = 0.354 (R) | 1.000 | (1.170,0.830-1.651) | P = 0.370 (R) | 1.000 | (1.313,0.991-1.740) | P = 0.058 (F) | 0.348 |
 6 studies | Cau/M Cau | 265/549 | (1.096,0.754-1.593) | P = 0.630 (R) | 1.000 | (1.153,0.538-2.471) | P = 0.714 (R) | 1.000 | (1.533,1.069-2.198) | P = 0.020 (F) | 0.120 |
 7 studies | East Asian | 167/949 | (1.030,0.785-1.351) | P = 0.830 (F) | 1.000 | (1.135,0.637-2.022) | P = 0.667 (F) | 1.000 | (0.906,0.507-1.617) | P = 0.737 (F) | 1.000 |
 1 study | Turkish | 10/92 | (2.038,0.795-5.225) | P = 0.138 | 0.828 | (4.909,0.480-50.178) | P = 0.180 | 1.000 | (0.773,0.175-3.415 | P = 0.734 | 1.000 |
 2 studies | Indian | 34/352 | (1.022,0.616-1.697) | P = 0.932 (F) | 1.000 | (1.157,0.452-2.965) | P = 0.761 (F) | 1.000 | (1.684,0.662-4.280 | P = 0.274 (F) | 1.000 |
 1 study | Iranian | 10/100 | (1.041,0.415-2.610) | P = 0.932 | 1.000 | (1.095,0.141-8.485) | P = 0.931 | 1.000 | (0.889,0.166-4.755 | P = 0.891 | 1.000 |