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Table 1 Characteristics of included studies evaluating the association between the 5-HTTLPR polymorphism and the presence of IBS

From: The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies

Author

Year

Location

Ethnicity

Case and control selection

SNP method

HWE test

Pata C [20]

2002

Turkey

Turkish

Case: patients diagnosed with Rome I criteria

AS-PCR

 
    

Control: healthy volunteers without detailed descriptions of matching methods

 

P = 0.0196

Lee DY [21]

2004

Korea

East Asian

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.8526

Kim HJ [12]

2004

USA

Mostly Caucasian

Case: patients selected from a database of 752 patients with IBS

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.9564

Wang BM [22]

2004

China

East Asian

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy contrtols matched for age and gender

 

P = 0.1693

Yeo A [10]

2004

North America

Caucasian

Case: patients diagnosed with Rome I criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.7053

Zhang XM [23]

2006

China

East Asian

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy controls matched for age and gender

 

P = 0.9536

Park JM [11]

2006

Korea

East Asian

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.1976

Whitehead WE [24]

2006

USA

Mostly Caucasian

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.2376

Li Y [25]

2007

China

East Asian

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.5862

Saito YA [26]

2007

USA

Mostly Caucasia

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: no IBS patients matched for age, race and gender

 

P = 0.2372

Camilleri M [27]

2008

USA

Mostly Caucasian

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

NC

Kohen R [28]

2009

USA

Mostly Caucasia

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy volunteers matched for age, race and gender

 

P = 0.1479

Schmulson M [29]

2009

Mexico

Mexican

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.0000

Niesler B [30]

2010

UK

Caucasian

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy volunteers without detailed descriptions of matching methods

 

P = 0.5492

Sikander A [31]

2009

India

Indian

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy controls without detailed description of matching methods

 

P = 0.4341

Markoutsaki T [32]

2011

Greek

Caucasian

Case: patients diagnosed with Rome III criteria

PCR-RFLP

 
    

Control: healthy volunteers without detailed description of matching methods

 

P = 0.6973

Jiang ZD [33]

2012

USA

Mostly Caucasian

Case: patients diagnosed with Rome II criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.1063

Wang YM [34]

2012

China

East Asian

Case: patients diagnosed with Rome III criteria

AS-PCR

 
    

Control: healthy controls without detailed description of matching methods

 

P = 0.0000

Park CS [35]

2012

Korea

East Asian

Case: patients diagnosed with Rome III criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.3054

Zhang ZX [36]

2012

China

East Asian

Case: patients diagnosed with Rome III criteria

AS-PCR

 
    

Control: healthy volunteers matched for age, race and gender

 

P = 0.4531

Kumar S [37]

2012

India

Indian

Case: patients diagnosed with Rome III criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.3093

Saito YA [38]

2012

USA

Mostly Caucasia

Case: patients diagnosed with Rome III criteria

AS-PCR

 
    

Control: healthy examinees matched for age, race and gender

 

P = 0.5924

Colucci R [39]

2013

Italy

Caucasian

Case: patients diagnosed with Rome III criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.6459

Shiotani A [40]

2013

Japan

East Asian

Case: patients diagnosed with Rome III criteria

AS-PCR

 
    

Control: healthy controls without detailed descriptions of matching methods

 

P = 0.5780

Farjadian S [41]

2013

Iran

Iranian

Case: patients diagnosed with Rome III criteria

AS-PCR

 
    

Control: healthy examinees matched for age, race and gender

 

P = 0.2284

  1. SNP: single nucleotide polymorphism; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; AS-PCR: allele-specific polymerase chain reaction; HWE test: Hardy-Weinberg equilibrium test; NC: not able to calculated from raw data.