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Table 2 GSRS discomfort scores in partial PPI responders and in treatment-naïve patients with GERD before and after 2 weeks of PPI therapy

From: Symptom profile in partial responders to a proton pump inhibitor compared with treatment-naïve patients with gastroesophageal reflux disease: a post hoc analysis of two study populations

 

Partial PPI responders

Treatment-naïve patients

GSRS domain/item

Before PPI treatment

After 2 weeks of PPI treatment

 

(n = 577a)

(n = 203)

(n = 203)

Reflux domain

4.3 (4.2–4.4)

3.5 (3.3–3.7)

1.6 (1.5–1.7)

 Heartburn

4.4 (4.3–4.5)

3.7 (3.4–3.9)

1.6 (1.5–1.8)

 Regurgitation

4.2 (4.1–4.3)

3.3 (3.0–3.5)

1.6 (1.4–1.7)

Abdominal pain domain

3.4 (3.3–3.5)

3.1 (3.0–3.3)

2.0 (1.9–2.2)

 Abdominal pain

4.0 (3.9–4.2)

4.1 (3.9–4.3)

2.3 (2.1–2.5)

 Hunger pains

3.5 (3.3–3.6)

3.0 (2.8–3.2)

2.1 (1.9–2.3)

 Nausea

2.7 (2.6–2.8)

2.4 (2.1–2.6)

1.7 (1.5–1.8)

Indigestion syndrome

3.7 (3.6–3.8)

3.6 (3.4–3.7)

2.5 (2.3–2.6)

 Rumbling

3.3 (3.2–3.4)

3.2 (3.0–3.4)

2.3 (2.1–2.4)

 Bloated

3.7 (3.5–3.8)

3.8 (3.6–4.0)

2.6 (2.4–2.8)

 Burping

3.8 (3.7–3.9)

3.4 (3.2–3.7)

2.3 (2.1–2.4)

 Passing gas

3.8 (3.7–4.0)

3.8 (3.5–4.0)

2.7 (2.5–2.9)

Diarrhea syndrome

2.1 (2.0–2.2)

2.2 (2.0–2.4)

1.7 (1.6–1.9)

 Diarrhea

1.9 (1.8–2.0)

2.2 (2.0–2.4)

1.8 (1.6–1.9)

 Loose stools

2.1 (1.9–2.2)

2.2 (2.0–2.4)

1.7 (1.6–1.8)

 Urgent need for bowel movement

2.4 (2.3–2.5)

2.3 (2.1–2.5)

1.8 (1.6–1.9)

Constipation syndrome

2.5 (2.4–2.6)

2.1 (1.9–2.2)

1.8 (1.6–1.9)

 Constipation

2.4 (2.3–2.6)

1.9 (1.7–2.1)

1.7 (1.5–1.8)

 Hard stools

2.2 (2.1–2.4)

1.9 (1.8–2.1)

1.6 (1.5–1.8)

 Feeling of incomplete bowel movement

2.7 (2.6–2.9)

2.4 (2.2–2.6)

2.0 (1.8–2.2)

  1. PPI treatment comprised esomeprazole 40 mg once daily for 2 weeks. Mean (95% CI) domain and item discomfort scores of the GSRS are shown. The degree of discomfort was rated on a 7-point Likert scale (1, no discomfort at all; 7, very severe discomfort).
  2. aGSRS data were unavailable for 3 patients in the partial PPI responders group.
  3. SD, standard deviation.