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Table 6 Mean quality of life scores before transoral fundoplication (TF) and at 6- and 12- month follow-up in patients initially randomized to the transoral fundoplication (TF) group

From: Efficacy of transoral fundoplication for treatment of chronic gastroesophageal reflux disease incompletely controlled with high-dose proton-pump inhibitors therapy: a randomized, multicenter, open label, crossover study

Parameters Baseline (Before TF on PPIs) 6-month (off PPIs) 12-month (off PPIs) p value (6-month vs. baseline) p value (12-month vs. baseline) p value (6-month vs. 12-month)
Reflux disease questionnaire (RDQ) 2.91 (1.32) 0.35 (0.53) 0.50 (0.73) < 0.001 < 0.001 0.772
 Heartburn (RDQ) 2.99 (2.55) 0.45 (0.86) 0.63 (1.01) < 0.001 < 0.001 0.776
 Dyspepsia (RDQ) 2.81 (1.57) 0.42 (0.83) 0.53 (0.88) < 0.001 < 0.001 0.917
 Regurgitation (RDQ) 2.94 (1.45) 0.19 (0.40) 0.33 (0.69) < 0.001 < 0.001 0.791
Gastroesophageal reflux disease health-related quality of life (GERD-HRQL) 26.25 (10.51) 5.23 (7.14) 5.41 (6.80) < 0.001 < 0.001 0.995
 Heartburn (GERD-HRQL) 17.69 (7.51) 3.74 (5.51) 3.76 (4.50) < 0.001 < 0.001 > 0.999
 Reflux Symptom Index 22.00 (9.63) 4.64 (5.53) 4.79 (6.67) < 0.001 < 0.001 0.995
 Hoarseness 1.76 (1.56) 0.18 (0.60) 0.33 (0.90) < 0.001 < 0.001 0.810
 Throat clearing 2.90 (1.37) 0.87 (1.28) 0.72 (1.10) < 0.001 < 0.001 0.851
 Excess throat mucus or postnasal drip 2.77 (1.51) 0.87 (1.20) 0.79 (1.06) < 0.001 < 0.001 0.961
 Difficulty swallowing foods, liquids or pills 1.92 (1.44) 0.33 (0.77) 0.46 (0.88) < 0.001 < 0.001 0.858
 Coughing after eating or after lying down 2.46 (1.54) 0.44 (1.02) 0.44 (0.88) < 0.001 < 0.001 > 0.999
 Breathing difficulties or choking episodes 1.85 (1.60) 0.13 (0.41) 0.33 (0.96) < 0.001 < 0.001 0.690
 Troublesome or annoying cough 2.21 (1.49) 0.49 (1.19) 0.54 (1.12) < 0.001 < 0.001 0.983
 Sensation or something sticking or a lump in the throat (globus) 2.74 (1.41) 0.41 (0.94) 0.44 (0.75) < 0.001 < 0.001 0.994
 Heartburn, chest pain, indigestion or stomach acid coming up 3.38 (1.39) 0.92 (1.22) 0.87 (1.26) < 0.001 < 0.001 0.983
Excess flatulence 2.36 (1.65) 0.72 (1.19) 0.68 (1.1) < 0.001 < 0.001 0.990
  1. Values represent means (standard deviations).