Table 6 Mean quality of life scores before transoral fundoplication (TF) and at 6- and 12- month follow-up in patients initially randomized to the transoral fundoplication (TF) group

Reflux disease questionnaire (RDQ)

2.91 (1.32)

0.35 (0.53)

0.50 (0.73)

< 0.001

< 0.001

0.772

 Heartburn (RDQ)

2.99 (2.55)

0.45 (0.86)

0.63 (1.01)

< 0.001

< 0.001

0.776

 Dyspepsia (RDQ)

2.81 (1.57)

0.42 (0.83)

0.53 (0.88)

< 0.001

< 0.001

0.917

 Regurgitation (RDQ)

2.94 (1.45)

0.19 (0.40)

0.33 (0.69)

< 0.001

< 0.001

0.791

Gastroesophageal reflux disease health-related quality of life (GERD-HRQL)

26.25 (10.51)

5.23 (7.14)

5.41 (6.80)

< 0.001

< 0.001

0.995

 Heartburn (GERD-HRQL)

17.69 (7.51)

3.74 (5.51)

3.76 (4.50)

< 0.001

< 0.001

> 0.999

 Reflux Symptom Index

22.00 (9.63)

4.64 (5.53)

4.79 (6.67)

< 0.001

< 0.001

0.995

 Hoarseness

1.76 (1.56)

0.18 (0.60)

0.33 (0.90)

< 0.001

< 0.001

0.810

 Throat clearing

2.90 (1.37)

0.87 (1.28)

0.72 (1.10)

< 0.001

< 0.001

0.851

 Excess throat mucus or postnasal drip

2.77 (1.51)

0.87 (1.20)

0.79 (1.06)

< 0.001

< 0.001

0.961

 Difficulty swallowing foods, liquids or pills

1.92 (1.44)

0.33 (0.77)

0.46 (0.88)

< 0.001

< 0.001

0.858

 Coughing after eating or after lying down

2.46 (1.54)

0.44 (1.02)

0.44 (0.88)

< 0.001

< 0.001

> 0.999

 Breathing difficulties or choking episodes

1.85 (1.60)

0.13 (0.41)

0.33 (0.96)

< 0.001

< 0.001

0.690

 Troublesome or annoying cough

2.21 (1.49)

0.49 (1.19)

0.54 (1.12)

< 0.001

< 0.001

0.983

 Sensation or something sticking or a lump in the throat (globus)

2.74 (1.41)

0.41 (0.94)

0.44 (0.75)

< 0.001

< 0.001

0.994

 Heartburn, chest pain, indigestion or stomach acid coming up

3.38 (1.39)

0.92 (1.22)

0.87 (1.26)

< 0.001

< 0.001

0.983

Excess flatulence

2.36 (1.65)

0.72 (1.19)

0.68 (1.1)

< 0.001

< 0.001

0.990