Table 1 Demographics and clinical characteristics of the study patients at screening

Male, n (%)

19 (49)

8 (38)

0.587

Age, years

54.5 (10.4)

50.4 (9.8)

0.151

Body mass index, kg/m²

28.3 (3.9)

29.1 (2.8)

0.422

GERD symptom duration, years

12.5 (11.3)

9.4 (5.7)

0.224

PPI therapy duration, years

9.3 (7.2)

8.1 (5.1)

0.686

Quality of life scores off PPIs

 Reflux Disease Questionnaire (RDQ) score

3.7 (1.1)

4.1 (0.7)

0.122

 Regurgitation (RDQ) score off PPIs

3.5 (1.2)

4.1 (0.9)

0.067

 GERD-HRQL score

32.5 (9.6)

33.7 (8.5)

0.625

 Heartburn score (GERD-HRQL)

22.2 (6.3)

23.2 (4.4)

0.519

 Reflux Symptom Index (RSI) score

25.2 (9.3)

28.6 (7.4)

0.150

Total % time pH <4

10.2 (3.5)

10.6 (3.5)

0.665

Patients on single dose of PPI at entry, n (%)

27 (69)

16 (76)

0.765