Figure 3From: Knockout of MIMP protein in lactobacillus plantarumlost its regulation of intestinal permeability on NCM460 epithelial cells through the zonulin pathway Loss of alleviation of intestinal permeability of LPKM induced by EPEC ex vivo . (A) The small intestinal permeability to mannitol in the IL-10-/- mice was increased, compared with the wild-type group. In LP group, the small intestinal permeability to mannitol significantly decreased, compared with control (P < 0.05). However, in LPKM group, the small intestinal permeability to mannitol did not changed significantly (P > 0.05). (B) Similar results were indicated for intestinal resistance. (C & D) Similar results were observed in colonic tissues. Colonic permeability to mannitol increased in the IL-10-/- mice with a corresponding decrease in TER, both of which were prevented by LP (P < 0.05). However, in LPKM group, colonic permeability to mannitol and TER did not changed significantly, compared with control (P > 0.05). Each group used 10 animals for determination. *vs. EPEC group, P < 0.05; # vs. *, P < 0.05. The data were expressed as the mean ± standard deviation. Statistical analyses were performed using the SPSS 13.0 software (SPSS Inc., Chicago, IL). Data were analyzed by one-way ANOVA when conditions of homogeneity of variance were present.Back to article page