Table 3 Characteristics of patients on PPI, stratified according to whether symptoms were non-troublesome or troublesome
Variable | Non-troublesome symptoms (N = 239) | Troublesome symptoms (N = 2367) | |
|---|---|---|---|
Age* | Mean ± SD | 56.5 ± 14.5 | 55.0 ± 13.2 |
Gender* | % females | 113 (47.3%) | 718 (41.7%)* |
Body mass index | Mean ± SD | 27.2 ± 3.5 | 27.1 ± 3.8 |
Alcohol* | Any | 121 (50.6%) | 1045 (60.7%)* |
Smoking | Current | 97 (40.5%) | 888 (51.6%) |
Former | 95 (39.7%) | 520 (30.2%)* | |
Concomitant therapy | Calcium blockers | 25 (10.5%) | 186 (10.8%) |
Nitrates | 6 (2.5%) | 53 (3.1%) | |
NSAIDs | 28 (11.7%) | 201 (11.7%) | |
ASA | 13 (5.4%) | 96 (5.6%) | |
Benzodiazepines | 44 (18.3%) | 367 (21.3%) | |
Comorbidity | Diabetes | 26 (10.8%) | 157 (9.1%) |
HBP | 86 (36.0%) | 608 (35.3%) | |
Hypercholesterolemia | 60 (25.1%) | 442 (25.7%) | |
Depression | 32 (13.4%) | 184 (10.7%) | |
Anxiety disorder | 52 (21.8%) | 434 (25.2%) | |
Asthma** | 16 (6.7%) | 55 (3.2%) | |
Frequency of symptoms+ | |||
Heartburn | Never | 69 (28.9%) | 211 (8.9%) |
Sometimes | 108 (45.2%) | 1036 (43.8%) | |
Often | 53 (22.2%) | 854 (36.1%) | |
Daily | 9 (3.8%) | 265 (11.2%) | |
Acid regurgitation | Never | 72 (30.1%) | 212 (9.0%) |
Sometimes | 120 (50.2%) | 1008 (42.9%) | |
Often | 38 (15.9%) | 880 (37.5%) | |
Daily | 9 (3.8%) | 248 (10.6%) | |
Chest pain | Never | 112 (46.9%) | 565 (23.9%) |
Sometimes | 89 (37.2%) | 1054 (44.5%) | |
Often | 29 (12.1%) | 614 (26.0%) | |
Daily | 9 (3.8%) | 133 (5.6%) | |
Epigastric burning/pain | Never | 58 (24.3%) | 284 (12.0%) |
Sometimes | 121 (50.6%) | 984 (41.6%) | |
Often | 49 (20.5%) | 872 (36.8%) | |
Daily | 11 (4.6%) | 227 (9.6%) | |
Hoarseness | Never | 131 (55.5%) | 784 (33.3%) |
Sometimes | 70 (29.7%) | 1003 (42.6%) | |
Often | 24 (10.2%) | 473 (20.1%) | |
Daily | 11 (4.7%) | 97 (4.1%) | |
Impact of symptoms+ | |||
Sleep disturbance** | Never | 96 (40.2%) | 385 (16.3%) |
Sometimes | 99 (41.4%) | 1213 (51.3%) | |
Often | 39 (16.3%) | 666 (28.2%) | |
Daily | 5 (2.1%) | 100 (4.2%) | |
Eating disturbance** | Never | 87 (36.4%) | 396 (16.8%) |
Sometimes | 107 (44.8%) | 1079 (45.6%) | |
Often | 37 (15.5%) | 756 (32.0%) | |
Daily | 8 (3.3%) | 133 (5.6%) | |
Disturbance of work** | Never | 135 (56.5%) | 801 (33.9%) |
Sometimes | 78 (32.6%) | 1062 (44.9%) | |
Often | 21 (8.8%) | 440 (18.6%) | |
Daily | 5 (2.1%) | 61 (2.6%) |