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Table 3 Characteristics of patients on PPI, stratified according to whether symptoms were non-troublesome or troublesome

From: Is the reflux disease questionnaire useful for identifying GERD according to the Montreal definition?

  Variable Non-troublesome symptoms (N = 239) Troublesome symptoms (N = 2367)
Age* Mean ± SD 56.5 ± 14.5 55.0 ± 13.2
Gender* % females 113 (47.3%) 718 (41.7%)*
Body mass index Mean ± SD 27.2 ± 3.5 27.1 ± 3.8
Alcohol* Any 121 (50.6%) 1045 (60.7%)*
Smoking Current 97 (40.5%) 888 (51.6%)
Former 95 (39.7%) 520 (30.2%)*
Concomitant therapy Calcium blockers 25 (10.5%) 186 (10.8%)
Nitrates 6 (2.5%) 53 (3.1%)
NSAIDs 28 (11.7%) 201 (11.7%)
ASA 13 (5.4%) 96 (5.6%)
Benzodiazepines 44 (18.3%) 367 (21.3%)
Comorbidity Diabetes 26 (10.8%) 157 (9.1%)
HBP 86 (36.0%) 608 (35.3%)
Hypercholesterolemia 60 (25.1%) 442 (25.7%)
Depression 32 (13.4%) 184 (10.7%)
Anxiety disorder 52 (21.8%) 434 (25.2%)
Asthma** 16 (6.7%) 55 (3.2%)
Frequency of symptoms+    
Heartburn Never 69 (28.9%) 211 (8.9%)
  Sometimes 108 (45.2%) 1036 (43.8%)
  Often 53 (22.2%) 854 (36.1%)
  Daily 9 (3.8%) 265 (11.2%)
Acid regurgitation Never 72 (30.1%) 212 (9.0%)
  Sometimes 120 (50.2%) 1008 (42.9%)
  Often 38 (15.9%) 880 (37.5%)
  Daily 9 (3.8%) 248 (10.6%)
Chest pain Never 112 (46.9%) 565 (23.9%)
  Sometimes 89 (37.2%) 1054 (44.5%)
  Often 29 (12.1%) 614 (26.0%)
  Daily 9 (3.8%) 133 (5.6%)
Epigastric burning/pain Never 58 (24.3%) 284 (12.0%)
  Sometimes 121 (50.6%) 984 (41.6%)
  Often 49 (20.5%) 872 (36.8%)
  Daily 11 (4.6%) 227 (9.6%)
Hoarseness Never 131 (55.5%) 784 (33.3%)
  Sometimes 70 (29.7%) 1003 (42.6%)
  Often 24 (10.2%) 473 (20.1%)
  Daily 11 (4.7%) 97 (4.1%)
Impact of symptoms+    
Sleep disturbance** Never 96 (40.2%) 385 (16.3%)
  Sometimes 99 (41.4%) 1213 (51.3%)
  Often 39 (16.3%) 666 (28.2%)
  Daily 5 (2.1%) 100 (4.2%)
Eating disturbance** Never 87 (36.4%) 396 (16.8%)
  Sometimes 107 (44.8%) 1079 (45.6%)
  Often 37 (15.5%) 756 (32.0%)
  Daily 8 (3.3%) 133 (5.6%)
Disturbance of work** Never 135 (56.5%) 801 (33.9%)
  Sometimes 78 (32.6%) 1062 (44.9%)
  Often 21 (8.8%) 440 (18.6%)
  Daily 5 (2.1%) 61 (2.6%)
  1. Cont. + According to GERD Impact Scale.
  2. *p < 0.05, **p < 0.001 (troublesome versus non-troublesome symptoms; chi-squared test).