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Table 1 Characteristics of patients off PPI, stratified according to whether symptoms were non-troublesome or troublesome

From: Is the reflux disease questionnaire useful for identifying GERD according to the Montreal definition?

  Variable Non-troublesome symptoms (N = 246) Troublesome symptoms (N = 1722)
Age* Mean ± SD 50.0 ± 12.3 52.0 ± 12.8
Gender* % females 123 (50%) 739 (42.9%)
Body mass index Mean ± SD 26.3 ± 3.7 26.9 ± 3.7
Alcohol* Any 188 (76.3%) 1233 (71.6%)
Smoking Current 122 (49.9%) 928 (53.9%)
Former 69 (28%) 408 (23.7%)
Concomitant therapy Calcium blockers 12 (4.9%) 129 (7.5%)
Nitrates 3 (1.2%) 17 (1.0%)
NSAIDs 22 (8.9%) 201 (11.7%)
ASA 9 (3.6%) 86 (5.0%)
Benzodiazepines 29 (11.8%) 219 (12.7%)
Comorbidity Diabetes 17 (6.9%) 141 (8.2%)
Hypertension 63 (25.6%) 513 (29.8%)
Hypercholesterolaemia** 36 (14.6%) 410 (23.9%)
Depression 14 (5.7%) 139 (8.1%)
Anxiety disorder 53 (21.5%) 387 (22.5%)
  Asthma 9 (3.6%) 77 (4.5%)
Frequency of symptoms+    
Heartburn** Never 46 (18.8%) 124 (7.2%)
  Sometimes 143 (58.4%) 708 (41.1%)
  Often 48 (19.6%) 699 (40.6%)
  Daily 8 (3.3%) 191 (11.1%)
Acid regurgitation** Never 65 (26.9%) 123 (7.2%)
  Sometimes 139 (57.4%) 739 (43.1%)
  Often 34 (14.0%) 661 (38.5%)
  Daily 4 (1.7%) 193 (11.2%)
Chest pain** Never 127 (51.8%) 444 (25.8%)
  Sometimes 93 (38.0%) 767 (44.5%)
  Often 21 (8.6%) 429 (24.9%)
  Daily 4 (1.6%) 82 (4.8%)
Epigastric burning/pain** Never 66 (26.8%) 184 (10.7%)
  Sometimes 136 (55.3%) 732 (42.5%)
  Often 39 (15.9%) 643 (37.3%)
  Daily 5 (2.0%) 163 (9.5%)
Hoarseness** Never 157 (64.6%) 582 (33.9%)
  Sometimes 68 (28.0%) 749 (43.6%)
  Often 15 (6.2%) 315 (18.3%)
  Daily 3 (1.2%) 73 (4.2%)
Impact of symptoms+    
Sleep disturbance** Never 106 (43.3%) 233 (13.5%)
  Sometimes 115 (46.9%) 938 (54.5%)
  Often 24 (9.8%) 478 (27.8%)
  Daily 0 (0.0%) 72 (4.2%)
Eating disturbance** Never 104 (42.4%) 276 (16.0%)
  Sometimes 116 (47.3%) 890 (51.7%)
  Often 23 (9.4%) 476 (27.6%)
  Daily 2 (0.8%) 80 (4.6%)
Disturbance of work** Never 164 (66.9%) 620 (36.0%)
  Sometimes 59 (24.1%) 774 (45.0%)
  Often 20 (8.2%) 279 (16.2%)
  Daily 2 (0.8%) 48 (2.8%)
  1. Cont. + According to GERD Impact Scale.
  2. *p < 0.05, **p < 0.001 (troublesome versus non-troublesome symptoms; chi-squared test).