TY - JOUR AU - Steinebrunner, Niels AU - Mogler, Carolin AU - Vittas, Spiros AU - Hoyler, Birgit AU - Sandig, Catharina AU - Stremmel, Wolfgang AU - Eisenbach, Christoph PY - 2014 DA - 2014/08/19 TI - Pharmacologic cholinesterase inhibition improves survival in acetaminophen-induced acute liver failure in the mouse JO - BMC Gastroenterology SP - 148 VL - 14 IS - 1 AB - Acetaminophen (APAP) is one of the most widely used analgesic and antipyretic pharmaceutical substances in the world and accounts for most cases of drug induced liver injury resulting in acute liver failure. Acute liver failure initiates a sterile inflammatory response with release of cytokines and innate immune cell infiltration in the liver. This study investigates, whether pharmacologic acetylcholinesterase inhibition with neostigmine diminishes liver damage in acute liver failure via the cholinergic anti-inflammatory pathway. SN - 1471-230X UR - https://doi.org/10.1186/1471-230X-14-148 DO - 10.1186/1471-230X-14-148 ID - Steinebrunner2014 ER -