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Table 3 Indications, MRE findings and clinical outcome of pregnant CD patients

From: Magnetic resonance enterography in pregnant women with Crohn’s disease: case series and literature review

Patient number CD status prior to pregnancy Pregnancy number/week Indication for MR Principal MRE findings Clinical management Clinical outcome Pregnancy outcome
1 20 years duration 1/23 Clinical exacerbation of known CD Phlegmon, sinus tract and fistula Prednisone therapy and IV antibiotics No improvement on medical treatment  
Inflammatory phenotype
Ileocolonic distribution
No current treatment
   1/26 Clinical exacerbation Small abscess 3 weeks later Abscess not accessible to drainage, conservative treatment with steroids and IV antibiotics Clinical deterioration, surgical intervention one month post-delivery, including ileostomy and cecectomy. Spontaneous VD at 34 weeks, healthy newborn
2 9 years duration 2/19 Clinical exacerbation of known CD Active disease, no complications, no obstruction Addition of IV steroids Clinical response and discharge Spontaneous VD at 38 weeks, healthy newborn
Inflammatory phenotype
Ileocolonic distribution
Tx: Azathioprine
3 16 years duration 1/31 Clinical exacerbation of known CD new onset of cholestasis Scant signs of active disease, no complications, no obstruction UDCA and prednisone added to maintenance treatment with 6 MP Improvement of CD symptoms, persistent cholestasis Induced preterm vaginal delivery for cholestatsis at 35 weeks healthy newborn
Fibrostenotic phenotype
s/p ileocecectomy
Ileocolonic distribution
Tx: 6-MP
4 15 years duration 2/22 Clinical exacerbation of known CD Active disease phlegmon and fistulae Enteral nutrition modulation a Partial response phlegmon and fistulae in CT post- delivery, antibiotics: Adalimumab was after delivery Spontaneous vaginal delivery at 38 weeks, healthy newborn
Fibrostenotic and inflammatory phenotype
Ileocolonic distribution
Tx: Azathioprine
5 4 years duration 1/37 Clinical exacerbation of known CD preeclampsia Some signs of active disease, no complications IV steroids and antibiotics Preeclampsia Urgent delivery Spontaneous onset of labor, vaginal delivery converted to C/S, at 37 weeks healthy newborn
Inflammatory phenotype
Inactive perianal disease
Crohn’s colitis
Tx: infliximab
6 10 years duration 2/20 Recurrent abscess in right groin, fistula? Phlegmon in RLQ fistula to right groin IV and PO antibiotics and abscess drainage prior to MR Clinical improvement Spontaneous delivery, healthy newborn at week 38
Inflammatory phenotype
Ileocolonic distribution
Tx: Azathioprine
7 2 years duration 2/25 Clinical exacerbation of known CD Signs of active disease, new phlegmon in RLQ Conservative treatment with steroids and IV antibiotics emergency cerclage Temporary clinical improvement hypoalumiemia & anasarca Spontaneous vaginal delivery at 28 weeks healthy very low birth weight newborn
Inflammatory phenotype
Ileocolonic distribution
Tx: 6-MP and adalimumab
8 No known disease 1/26 Suspected CD Bowel normal No treatment Abdominal symptoms resolved Healthy twins newborns C/S at 32 w
9 No known disease ?/11 Uncertain diagnosis of UC, suspected CD MRE signs of UC NA NA Spontaneous delivery with a healthy newborn at week 41S
  1. UC-ulcerative colitis, VD- vaginal delivery, RQ-right lower quadrant, 6-mp- 6-mercaptopurine, UDCA-ursodeoxycholic acid.