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Table 4 Multivariable ordinal regression models for inflammation stage and fibrosis stage

From: Alpha-fetoprotein level as a biomarker of liver fibrosis status: a cross-sectional study of 619 consecutive patients with chronic hepatitis B

 

Ordinal regression model for inflammation stage

Ordinal regression model for fibrosis stage

Coefficient (95% CI)

Coefficient (95% CI) in exponential scale

P-value

Coefficient (95% CI)

Coefficient (95% CI) in exponential scale

P-value

Threshold

      

stage 0/stage 1-4

−5.16 (−6.96, −3.37)

0.01 (0.00, 0.03)

<0.001

−2.44 (−3.59, −1.29)

0.09 (0.03, 0.27)

<0.001

stage 0–1/stage 2-4

−1.17 (−2.30, −0.03)

0.31 (0.10, 0.97)

0.044

−0.37 (−1.47, 0.73)

0.69 (0.23, 2.07)

0.507

stage 0–2/stage 3-4

0.45 (−0.67, 1.58)

1.57 (0.51, 4.84)

0.432

0.79 (−0.30, 1.89)

2.21 (0.74, 6.61)

0.157

stage 0-3/stage 4

2.96 (1.80, 4.12)

19.32 (6.08, 61.42)

<0.001

1.85 (0.74, 2.95)

6.33 (2.10, 19.12)

0.001

Independent variables

      

Age (year)

0.00 (−0.01, 0.02)

1.00 (0.99, 1.02)

0.665

0.02 (0.00, 0.03)

1.02 (1.00, 1.03)

0.011*

Female to male

0.41 (0.01, 0.82)

1.51 (1.01, 2.27)

0.047*

0.23 (−0.17, 0.63)

1.26 (0.85, 1.88)

0.252

logAFP

0.47 (0.35, 0.59)

1.60 (1.42, 1.81)

<0.001*

0.53 (0.40, 0.65)

1.70 (1.50, 1.92)

<0.001*

logGGT

0.14 (−0.10, 0.39)

1.15 (0.90, 1.47)

0.259

−0.11 (−0.35, 0.13)

0.90 (0.71, 1.14)

0.363

logAPRI

0.63 (0.43, 0.83)

1.88 (1.54, 2.29)

<0.001*

0.36 (0.17, 0.55)

1.43 (1.18, 1.73)

<0.001*

  1. *P < 0.05 indicates the corresponding variable was significantly associated to inflammation stage or fibrosis stage. APRI = AST/PLT, AST and ALT were excluded from both models due to its colinearity to APRI.