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Table 1 Zinc serum levels and jejunal morphometrics in experimental rats challenged by lactose-induced diarrhea and the regional northeast basic diet with their respective controls

From: Zinc treatment ameliorates diarrhea and intestinal inflammation in undernourished rats

  Nourished Undernourished
Outcomes PBS PBS P Zn P (Zn vs PBS) Lac Zn + lac P (Zn + Lac vs Lac)
Biochemisty         
Zinc serum levels (mg/L) (n) 1.089 ± 0.08 (n = 11) 0.712 ± 0.10 (n = 10) < 0.0001 1.57 ± 0.12 (n = 8) < 0.0001 1.12 ± 0.24 (n = 12) 2.04 ± 0.50 (n = 8) < 0.0001
Jejunal morphology*         
Villus height (μm) 826.3 ± 92.2 587.9 ± 98.3 < 0.0001 704.2 ± 113.9 0.001 686 ± 103.2 667.9 ± 78.2 0.359
Crypt length (μm) 151.5 ± 36.5 187.7 ± 66.7 < 0.0001 169.8 ± 49.0 0.007 141.6 ± 27.7 127.2 ± 20.3 < 0.0001
Villus/crypt ratio 6.03 ± 1.7 3.7 ± 1.4 < 0.0001 5.15 ± 2.82 0.0322 5.1 ± 0.8 5.4 ± 1.19 0.235
  1. *At least 40 sections of jejunal villi and crypts stained with hematoxylin and eosin in at least four animals per group. Data are presented as mean ± SD. Comparisons were performed by Student’s unpaired t test. Villi and crypts were measured only when their full longitudinal axis was found.
  2. Zn = zinc treated-rats; Lac = lactose challenged-rats.