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Table 5 Biochemical measurements of patients

From: Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C

Treat < 2 years 2 years Intention to treat
No. patients 6 28 34
Biochemical data Before After P value Before After P value Before After P value
ALT (mean ± SD) 67 ± 25 59 ± 20 0.63 85 ± 71 65 ± 34 0.13 82 ± 68 64 ± 32 0.23
AST (mean ± SD) 95 ± 38 87 ± 38 1.0 94 ± 55 75 ± 38 0.02* 94 ± 54 78 ± 38 0.02*
Total Bilirubin (mean ± SD) 2 ± 1.7 3.1 ± 1.5 0.16 1 ± 0.8 1 ± 0.5 0.04* 1.4 ± 0.9 1.4 ± 1.1 0.46
Direct Bilirubin (mean ± SD) 0.8 ± 0.5 1.5 ± 0.9 0.03* 0.4 ± 0.3 0.4 ± 0.2 0.63 0.5 ± 0.3 0.6 ± 0.6 0.46
Indirect Bilirubin (mean ± SD) 1.3 ± 0.9 1.6 ± 0.9 0.56 0.8 ± 0.7 0.6 ± 0.4 0.05* 0.9 ± 0.7 0.8 ± 0.6 0.31
  1. ALT: Alanine transaminase; AST: Aspartate transaminase. *p< 0.05.