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Table 2 Logistic regression analysis on moderate to severe stage of fibrosis

From: FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B

   Stage > =2 (n = 15) n (%) or Mean (SD) Stage < 2 (n = 30) n (%) or Mean (SD)    Univariable logistic regression Multivariable logistic regression***
Variable   OR 95% CI p-value p-value
Age   46.87 (13.93) 40.17 (10.72) 1.05 0.993; 1.110 0.089  
Gender, N (%) Male 11 (42.31) 15 (57.69) 2.75 0.713; 10.605 0.1418 0.0641
  Female* 4 (21.05) 15 (78.95)     
Race, N (%) Caucasian* 1 (16.67) 5 (83.33)    0.2845  
  AA 9 (50.00) 9(50.00) 5 0.483; 51.769   
  Asian 4 (22.22) 14 (77.78) 1.429 0.127; 16.025   
  Other 1 (33.33) 2 (66.67) 2.5 0.1; 62.602   
Diagnosis HBV 7 (21.21) 26 (78.79) 0.135 0.031; 0.581 0.0072** 0.0156**
  HIV/HBV* 8 (66.67) 4 (33.33)     
Inflammation Grade > 1 12 (57.14) 9 (42.86) 9.333 2.110; 41.278 0.0032** 0.0066**
  Grade < =1* 3 (12.50) 21 (87.50)     
FibroSURE   0.462 (0.297) 0.212 (0.167) 3.015§ 1.426; 6.374 0.0039** 0.0158**
log10 ALT (U/L)   1.81 (0.25) 1.52 (0.28) 3.314§ 1.393; 7.883 0.0067**  
log10 AST (U/L)   1.70 (0.21) 1.51 (0.25) 2.455§ 1.065; 5.658 0.0350**  
log10 HBV DNA (IU/ml) 5.24 (2.98) 4.60 (2.39) 1.304§ 0.674; 2.520 0.4303  
  1. *Reference group for the reported odds ratios.
  2. **p-value < 0.05.
  3. ***Based on the best selected model.
  4. §OR of 1 SD increase.
  5. Abbreviations: ALT alanine aminotransferase, AST aspartate aminotransferase, HBV hepatitis B virus, SD standard deviation, OR odds ratio, CI confidence interval, AA African-American, HIV human immunodefiency virus.