FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B

BMC Gastroenterology

Table 2 Logistic regression analysis on moderate to severe stage of fibrosis

		Stage > =2 (n = 15) n (%) or Mean (SD)	Stage < 2 (n = 30) n (%) or Mean (SD)			Univariable logistic regression	Multivariable logistic regression***
Variable		Stage > =2 (n = 15) n (%) or Mean (SD)	Stage < 2 (n = 30) n (%) or Mean (SD)	OR	95% CI	p-value	p-value
Age		46.87 (13.93)	40.17 (10.72)	1.05	0.993; 1.110	0.089
Gender, N (%)	Male	11 (42.31)	15 (57.69)	2.75	0.713; 10.605	0.1418	0.0641
	Female*	4 (21.05)	15 (78.95)
Race, N (%)	Caucasian*	1 (16.67)	5 (83.33)			0.2845
	AA	9 (50.00)	9(50.00)	5	0.483; 51.769
	Asian	4 (22.22)	14 (77.78)	1.429	0.127; 16.025
	Other	1 (33.33)	2 (66.67)	2.5	0.1; 62.602
Diagnosis	HBV	7 (21.21)	26 (78.79)	0.135	0.031; 0.581	0.0072**	0.0156**
	HIV/HBV*	8 (66.67)	4 (33.33)
Inflammation	Grade > 1	12 (57.14)	9 (42.86)	9.333	2.110; 41.278	0.0032**	0.0066**
	Grade < =1*	3 (12.50)	21 (87.50)
FibroSURE		0.462 (0.297)	0.212 (0.167)	3.015^§	1.426; 6.374	0.0039**	0.0158**
log₁₀ ALT (U/L)		1.81 (0.25)	1.52 (0.28)	3.314^§	1.393; 7.883	0.0067**
log₁₀ AST (U/L)		1.70 (0.21)	1.51 (0.25)	2.455^§	1.065; 5.658	0.0350**
log₁₀ HBV DNA (IU/ml)		5.24 (2.98)	4.60 (2.39)	1.304^§	0.674; 2.520	0.4303

*Reference group for the reported odds ratios.
**p-value < 0.05.
***Based on the best selected model.
^§OR of 1 SD increase.
Abbreviations: ALT alanine aminotransferase, AST aspartate aminotransferase, HBV hepatitis B virus, SD standard deviation, OR odds ratio, CI confidence interval, AA African-American, HIV human immunodefiency virus.

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