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Table 4 Cox regression analysis for factors influencing survival in patients with HCC in NCL

From: Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver

Variables (SI-units if not indicated otherwise)

Univariate analysis

Multivariate analysis

HR

95% CI

p

HR

95% CI

p

Age (≤65 years vs > 65 years)

1.598

0.957-2.669

0.073

   

Sex (m vs f)

0.777

0.457-1.332

0.352

   

BMI (≤30 kg/m2 vs > 30 kg/m2)

0.573

0.216-1.518

0.263

   

Etiology (alcohol vs viral vs other)

  

0.095

   

BCLC stage

  

0.014

   

CLIP

  

0.031

   

Size of largest nodule (>5 cm vs ≤ 5 cm)

1.991

0.993-3.992

0.052

   

Portal vein thrombosis (yes vs no)

1.859

1.066-3.241

0.029

1.559

0.676-3.596

0.298

Extrahepatic metastasis (yes vs no)

2.104

1.248-3.549

0.005

2.844

1.098-7.368

0.031

Ascites

1.181

0.575-2.428

0.651

   

Number of lesions (one vs two vs multinodular)

  

0.204

   

Steatosis (yes vs no)

0.576

0.248-1.340

0.200

   

AFP

1.0

0.999-1.000

0.031

1.0

0.999-1.001

0.323

CA 19-9

1.0

0.999-1.001

0.969

   

Hemoglobin

0.963

0.790-1.174

0.709

   

ALAT

1.060

0.864-1.302

0.575

   

ASAT

1.158

1.000-1.340

0.050

0.999

0.629-1.586

0.997

Albumin

0.975

0.941-1.010

0.152

   

Bilirubin

1.001

0.997-1.006

0.484

   

Alcaline phosphatase

0.993

0.955-1.032

0.724

   

GGT

1.021

0.974-1.071

0.386

   

Quick

0.990

0.977-1.002

0.112

   

PTT

1.057

1.007-1.110

0.026

1.057

0.891-1.255

0.524

Platelets

1.002

1.000-1.004

0.049

1.004

1.001-1.007

0.006

Ferritin

1.0

1.000-1.001

0.455

   

Creatinine

0.997

0.992-1.002

0.231

   

Urea nitrogen

0.966

0.914-1.020

0.212

   

Diabetes mellitus (yes vs no)

1.246

0.564-2.753

0.586

   

Nicotine (yes vs no)

1.239

0.632-2.428

0.532

   

ECOG status (1 or 2 vs 0)

1.965

1.129- 3.417

0.017

1.645

0.681-3.968

0.269

Aim of treatment (palliative vs curative)

1.044

0.616-1.770

0.873

   
  1. p-values indicating a statistical significance are printed in bold.