Clinical characteristics of elderly patients with proton pump inhibitor-refractory non-erosive reflux disease from the G-PRIDE study who responded to rikkunshito

Table 4 The differences in clinical characteristics between the RKT responsive group and RKT nonresponsive group

	Responders (n = 25)	Non-responders (n = 17)	P value
Mean age, years (range)	71.12(65-85)	73.12(65-85)	0.441^a
Gender, n, (M/F)	10/15	4/13	0.331^b
BMI (mean ± SD)	23.5 ± 4.1	22.3 ± 2.3	0.497^a
Current alcohol use (Y/N)	4/21	1/16	0.632^b
Current smoking (Y/N)	5/20	0/17	0.070^b
Helicobacter pylori infection (Y/N)	6/8	4/6	1.000^b
Gastric mucosal atrophy,	18/7	11/6	0.738^b
Redness of gastric mucosa (Y/N)	5/20	2/15	0.681^b
GEFV(grade I&II/III&IV)	17/8	10/7	0.744^b
Esophageal hiatal hernia (grade O&C/B&A)	13/12	9/8	1.000^b
Concomitant systemic diseases(Y/N))	13/12	15/2	0.020^b
Total FSSG score (mean ± SD)	15.9 ± 7.4	14.6 ± 6.5	0.616^a
Total GSRS score (mean ± SD)	2.5 ± 1.0	2.3 ± 0.8	0.722^a

BMI, body mass index; GEFV, gastroesophageal flap valve; FSSG, Frequency Scale for the Symptoms of GERD; GSRS, Gastrointestinal Symptom Rating Scale.
^a, Wilcoxon’s rank sum test; ^b, Fisher’s exact test.

ISSN: 1471-230X