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Table 3 Genotype frequencies of MRC1 and IL28B single nucleotide polymorphisms in HCV-2 infected PEG-IFNα-RBV therapy patients with and without SVR in Taiwan Chinese population

From: Association of MRC-1 and IL-28Bwith the treatment outcome of hepatitis C: a case control study

MRC1 IL28B
Genotype SVR (+) SVR (−) P OR (95% CI) Genotype SVR(+) SVR (−) P OR (95% CI)
N (%) N (%) N (%) N (%)
( MRC1 ) rs1926736 ( IL28B ) rs955155
C/C 50 (28.1) 3 (17.6)   3.23 (0.75, 13.84) C/C 154 (86.5) 12 (70.6)   1
C/T 97 (54.5) 8 (47.1)   2.35 (0.76, 7.29) C/T 24 (13.5) 5 (29.4) 0.08 0.37 (0.12-1.16)
T/T 31 (17.4) 6 (35.3) 0.2 1 T/T 0 (0.0) 0 (0.0) - -
C/C + C/T 147 (82.6) 11 (64.7) 0.07 2.59 (0.89, 7.52) T/T + C/T 24 (13.5) 5 (29.4) 0.08 0.37 (0.12-1.16)
( MRC1 ) rs691005 ( IL28B ) rs8099917
C/C 16 (9.0) 4 (23.5)   0.19 (0.04, 0.82) T/T 155 (87.1) 10 (58.8)   1
C/T 76 (42.7) 9 (53.0)   0.39 (0.12, 1.33) T/G 23 (12.9) 7 (41.2) 0.002* 0.21 (0.07-0.61)
T/T 86 (48.3) 4 (23.5) 0.06 1 G/G 0 (0.0) 0 (0.0)   -
C/C + C/T 92 (51.7) 13 (76.5) 0.05 0.33 (0.10, 1.05) G/G + T/G 23 (12.9) 7 (41.2) 0.002* 0.21 (0.07-0.61)
  ( IL28B ) rs10853728
      C/C 116 (65.2) 6 (35.3)   1
      C/G 62 (34.8) 11 (64.7) 0.02* 0.29 (0.1-0.83)
      G/G 0 (0.0) 0 (0.0) - -
      G/G + C/G 62 (34.8) 11 (64.7) 0.02* 0.29 (0.1-0.83)
  1. Abbreviations: SNP, single nucleotide polymorphism; SVR, sustained virological response; OR, odds ratio; CI, confidence interval.
  2. Genotype frequencies were determined by χ2 test using 3 × 2 or 2 × 2 tables as appropriate. Odds ratios and 95% CI per genotype were estimated by applying unconditional logistic regression. The P values less than 0.05 were considered significant, and are denoted with an asterisk.