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Table 2 Typical GERD symptoms in the 5 classes (primary efficacy set N = 7434)

From: Classification of adults suffering from typical gastroesophageal reflux disease symptoms: contribution of latent class analysis in a European observational study

n (%) Class 1 Class 2 Class 3 Class 4 Class 5
N = 1598 N = 845 N = 2375 N = 1181 N = 1435
Heartburn      
 None 53 (3.3) 41 (4.9) 12 (0.5) 204 (17.3) 0
 Mild 325 (20.3) 310 (36.7) 599 (25.2) 369 (31.2) 684 (47.7)
 Moderate 913 (57.1) 423 (50.1) 1439 (60.6) 544 (46.1) 681 (47.5)
 Severe 307 (19.2) 71 (8.4) 325 (13.7) 64 (5.4) 70 (4.9)
Regurgitation      
 None 107 (6.7) 157 (18.6) 199 (8.4) 2 (0.2) 1063 (74.1)
 Mild 543 (34.0) 356 (42.1) 989 (41.6) 650 (55.0) 225 (15.7)
 Moderate 757 (47.4) 273 (32.3) 1031 (43.4) 465 (39.4) 130 (9.1)
 Severe 191 (12.0) 59 (7.0) 156 (6.6) 64 (5.4) 17 (1.2)
Number of days per week      
 1 day per week 70 (4.4) 171 (20.2) 131 (5.5) 159 (13.5) 258 (18.0)
 2 to 3 days per week 529 (33.1) 407 (48.2) 823 (34.7) 523 (44.3) 631 (44.0)
 4 to 5 days per week 546 (34.2) 171 (20.2) 804 (33.9) 279 (23.6) 309 (21.5)
 6 to 7 days per week 453 (28.3) 96 (11.4) 617 (26.0) 220 (18.6) 237 (16.5)
Time of occurrence      
 Only during the day 405 (25.3) 0 189 (8.0) 1094 (92.6) 1206 (84.0)
 Only during the night 1 (0.1) 845 (100) 0 0 0
 Both during day and night 1192 (74.6) 0 2186 (92.0) 87 (7.4) 229 (16.0)
  1. N = number of subjects.
  2. n = number of subjects with observations.