| |
Iron
|
Placebo
| |
|---|
|
Symptom
|
Treatment
|
Wash-out
|
Treatment
|
Wash-out
|
pvalue#
|
|---|
|
Nausea
|
1.1 ± 0.6
|
0.1 ± 0.1
|
0.2 ± 0.1
|
0.4 ± 0.4
|
0.2
|
|
(−0.3; 2.5)
|
(−0.1; 0.3)
|
(−0.1; 0.5)
|
(−0.5; 1.3)
|
|
Heartburn
|
1.0 ± 0.4
|
0.3 ± 0.3
|
0
|
0
|
0.03
|
|
(0.1; 1.9)
|
(−0.4; 1.0)
|
(0; 0)
|
(0; 0)
|
|
Abdominal pain
|
2.0 ± 0.6
|
1.0 ± 0.7
|
0.2 ± 0.1
|
0
|
0.02
|
|
(0.5; 3.5)
|
(−0.7; 2.7)
|
(−0.1; 0.5)
|
(0; 0)
|
|
Headache
|
1.1 ± 0.5
|
1.6 ± 0.6
|
0.2 ± 0.2
|
0.1 ± 0.1
|
0.15
|
|
(−0.1; 2.3)
|
(0.2; 3.0)
|
(−0.3; 0.7)
|
(−0.1; 0.3)
|
|
Breathlessness
|
0.1 ± 0.1
|
0.5 ± 0.3
|
0
|
0.1 ± 0.1
|
0.3
|
|
(−0.1; 0.3)
|
(−0.3; 1.3)
|
(0; 0)
|
(−0.1; 0.3)
|
|
Diarrohea
|
0.4 ± 0.3
|
0.3 ± 0.2
|
0.3 ± 0.3
|
0.4 ± 0.2
|
0.8
|
|
(−0.3; 1.1)
|
(−0.2; 0.8)
|
(−0.4; 1.0)
|
(−0.1; 0.9)
|
|
Constipation
|
1.0 ± 0.6
|
0.7 ± 0.5
|
0.2 ± 0.2
|
0
|
0.2
|
|
(−0.3; 2.3)
|
(−0.4; 1.8)
|
(−0.3; 0.7)
|
(0; 0)
|
|
Change bowel movements
|
1.3 ± 0.5
|
1.5 ± 0.3
|
0.4 ± 0.3
|
0.4 ± 0.2
|
0.15
|
|
(0.1; 2.5)
|
(0.7; 2.3)
|
(−0.2; 1.0)
|
(−0.1; 0.9)
|
|
Black stools
|
4.1 ± 0.7
|
1.3 ± 0.4
|
0
|
0
|
0.0004
|
|
(2.4; 5.8)
|
(0.4; 2.2)
|
(0; 0)
|
(0; 0)
|
| |
p = 0.002
| | | |
- Values, derived from boxes ‘C’ and ‘H’ of the questionnaire (Figure 1), are shown as mean ± standard error (95% confidence interval) for the two groups.
-
#significance value (p < 0.05) between the frequency of each symptom for the Iron treatment period versus the Placebo treatment period.
