Table 2 Frequency of individual symptoms irrespective of whether mild, moderate or severe (days per week)
| Â | Iron | Placebo | Â | ||
|---|---|---|---|---|---|
Symptom | Treatment | Wash-out | Treatment | Wash-out | pvalue# |
Nausea | 1.1 ± 0.6 | 0.1 ± 0.1 | 0.2 ± 0.1 | 0.4 ± 0.4 | 0.2 |
(−0.3; 2.5) | (−0.1; 0.3) | (−0.1; 0.5) | (−0.5; 1.3) | ||
Heartburn | 1.0 ± 0.4 | 0.3 ± 0.3 | 0 | 0 | 0.03 |
(0.1; 1.9) | (−0.4; 1.0) | (0; 0) | (0; 0) | ||
Abdominal pain | 2.0 ± 0.6 | 1.0 ± 0.7 | 0.2 ± 0.1 | 0 | 0.02 |
(0.5; 3.5) | (−0.7; 2.7) | (−0.1; 0.5) | (0; 0) | ||
Headache | 1.1 ± 0.5 | 1.6 ± 0.6 | 0.2 ± 0.2 | 0.1 ± 0.1 | 0.15 |
(−0.1; 2.3) | (0.2; 3.0) | (−0.3; 0.7) | (−0.1; 0.3) | ||
Breathlessness | 0.1 ± 0.1 | 0.5 ± 0.3 | 0 | 0.1 ± 0.1 | 0.3 |
(−0.1; 0.3) | (−0.3; 1.3) | (0; 0) | (−0.1; 0.3) | ||
Diarrohea | 0.4 ± 0.3 | 0.3 ± 0.2 | 0.3 ± 0.3 | 0.4 ± 0.2 | 0.8 |
(−0.3; 1.1) | (−0.2; 0.8) | (−0.4; 1.0) | (−0.1; 0.9) | ||
Constipation | 1.0 ± 0.6 | 0.7 ± 0.5 | 0.2 ± 0.2 | 0 | 0.2 |
(−0.3; 2.3) | (−0.4; 1.8) | (−0.3; 0.7) | (0; 0) | ||
Change bowel movements | 1.3 ± 0.5 | 1.5 ± 0.3 | 0.4 ± 0.3 | 0.4 ± 0.2 | 0.15 |
(0.1; 2.5) | (0.7; 2.3) | (−0.2; 1.0) | (−0.1; 0.9) | ||
Black stools | 4.1 ± 0.7 | 1.3 ± 0.4 | 0 | 0 | 0.0004 |
(2.4; 5.8) | (0.4; 2.2) | (0; 0) | (0; 0) | ||
|  | p = 0.002 |  |  |  | |