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Table 2 Ratios of COX-2 mRNA expression in paired colorectal tumor/normal mucosa, normalized with respect to tissue weight or to the levels of the housekeeping genes B2M or GAPDH

From: Over-expression of COX-2 mRNA in colorectal cancer

  Tissue weight B2M GAPDH
Number of pairs N = 60 N = 60 N = 55*
Mean ratio 21.6 16.1 7.5
Range 0.01-595.3 0.01-525.5 0.00-150.9
Ratio >1 (%)** 46 (77%) 42 (70%) 22 (40%)
Ratio <1 (%)*** 14 (23%) 18 (30%) 33 (60%)
  1. B2M, beta-2 microglobulin.
  2. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.
  3. *Note that GAPDH was not detectable or the analysis did not succeed in 5 cases.
  4. **Ratio > 1 means that COX-2 expression is higher in colorectal tumor tissue compared to paired normal mucosa.
  5. ***Ratio < 1 means that COX-2 expression is lower in colorectal tumor tissue compared to paired normal mucosa.