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Table 2 Ratios of COX-2 mRNA expression in paired colorectal tumor/normal mucosa, normalized with respect to tissue weight or to the levels of the housekeeping genes B2M or GAPDH

From: Over-expression of COX-2 mRNA in colorectal cancer

 

Tissue weight

B2M

GAPDH

Number of pairs

N = 60

N = 60

N = 55*

Mean ratio

21.6

16.1

7.5

Range

0.01-595.3

0.01-525.5

0.00-150.9

Ratio >1 (%)**

46 (77%)

42 (70%)

22 (40%)

Ratio <1 (%)***

14 (23%)

18 (30%)

33 (60%)

  1. B2M, beta-2 microglobulin.
  2. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.
  3. *Note that GAPDH was not detectable or the analysis did not succeed in 5 cases.
  4. **Ratio > 1 means that COX-2 expression is higher in colorectal tumor tissue compared to paired normal mucosa.
  5. ***Ratio < 1 means that COX-2 expression is lower in colorectal tumor tissue compared to paired normal mucosa.
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BMC Gastroenterology

ISSN: 1471-230X

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