|
GST
|
GST genotypes
|
Predicted enzyme activity
|
ESCC (n = 106)#
|
EAC (n = 327)#
|
Controls (n = 592)#
|
|---|
|
GST M1
|
*1/*1 & *1/*0
|
High-Intermediate
|
48 (45.7%)
|
156 (47.7%)
|
273 (46.2%)
|
|
*0/*0
|
Low
|
57 (54.3%)
|
171 (52.3%)
|
318 (53.8%)
|
|
GST A1
|
*1a/*1a
|
High
|
43 (41.3%)
|
131 (42.1%)
|
214 (37.2%)
|
|
*1a/*1b
|
Intermediate
|
50 (48.1%)
|
133 (42.8%)
|
277 (48.2%)
|
|
*1b/*1b
|
Low
|
11 (10.6%)
|
47 (15.1%)
|
84 (14.6%)
|
|
GST P1
I105V
|
Ile / Ile
|
High
|
48 (45.7%)
|
119 (37.5%)
|
246 (41.6%)
|
|
Ile / Val
|
Intermediate
|
42 (40.0%)
|
157 (49.5%)
|
261 (44.2%)
|
|
Val / Val
|
Low
|
15 (14.3%)
|
41 (12.9%)
|
84 (14.2%)
|
|
GST P1
A114V
|
Ala / Ala
|
High
|
92 (86.8%)
|
262 (82.6%)
|
485 (83.5%)
|
|
Ala / Val
|
Intermediate
|
14 (13.2%)
|
52 (16.4%)
|
91 (15.7%)
|
|
Val / Val
|
Low
|
0
|
3 (0.9%)
|
5 (0.9%)
|
|
GST T1
|
*1/*1 & *1/*0
|
High-Intermediate
|
87 (82.9%)
|
248 (75.8%)
|
463 (78.3%)
|
|
*0/*0
|
Low
|
18 (17.1%)
|
79 (24.2%)
|
128 (21.7%)
|
-
ESSC esophageal squamous cell carcinoma, EAC esophageal adenocarcinoma.
- #Some genotyping data were missing due to PCR bias.
