Skip to main content

Table 3 GST genotype distribution according to predicted enzyme activity

From: No role for glutathione S-transferase genotypes in Caucasian esophageal squamous cell or adenocarcinoma etiology: an European case–control study

GST GST genotypes Predicted enzyme activity ESCC (n = 106)# EAC (n = 327)# Controls (n = 592)#
GST M1 *1/*1 & *1/*0 High-Intermediate 48 (45.7%) 156 (47.7%) 273 (46.2%)
*0/*0 Low 57 (54.3%) 171 (52.3%) 318 (53.8%)
GST A1 *1a/*1a High 43 (41.3%) 131 (42.1%) 214 (37.2%)
*1a/*1b Intermediate 50 (48.1%) 133 (42.8%) 277 (48.2%)
*1b/*1b Low 11 (10.6%) 47 (15.1%) 84 (14.6%)
GST P1 I105V Ile / Ile High 48 (45.7%) 119 (37.5%) 246 (41.6%)
Ile / Val Intermediate 42 (40.0%) 157 (49.5%) 261 (44.2%)
Val / Val Low 15 (14.3%) 41 (12.9%) 84 (14.2%)
GST P1 A114V Ala / Ala High 92 (86.8%) 262 (82.6%) 485 (83.5%)
Ala / Val Intermediate 14 (13.2%) 52 (16.4%) 91 (15.7%)
Val / Val Low 0 3 (0.9%) 5 (0.9%)
GST T1 *1/*1 & *1/*0 High-Intermediate 87 (82.9%) 248 (75.8%) 463 (78.3%)
*0/*0 Low 18 (17.1%) 79 (24.2%) 128 (21.7%)
  1. ESSC esophageal squamous cell carcinoma, EAC esophageal adenocarcinoma.
  2. #Some genotyping data were missing due to PCR bias.