Skip to main content

Table 1 Patient characteristics

From: Diabetes mellitus impacts risk of macrovascular invasion in patients undergoing transplantation for hepatocellular carcinoma

Category Total (n=191) Diabetic (n=84) Non-Diabetic (n=107) P Value
Age (Mean ± StDev) 57.2 ± 8.6 60.7 ± 7.2 55.03 ± 8.9 < 0.0001
>65 years old (%) 40 (20.9%) 24 (28.6%) 16 (15.0%) 0.022
Sex (% Male) 164 (85.9%) 75 (89.3 %) 89 (83.2 %) 0.23
Body mass index > 30 78 (40.8%) 40 (47.6%) 42 (39.3%) 0.017
Etiologic Risk Factors *     
Alcohol abuse 47 (24.6%) 18 (21.4%) 29 (27.1%) 0.37
Hepatitis C 104 (54.5%) 37 (44%) 67 (62.6%) 0.011
Hepatitis B 12 (6.2%) 5 (5.9%) 7 (6.5%) 0.86
Non-alcoholic steatohepatitis 14 (7.3%) 11 (13.1%) 3 (2.8%) 0.007
Cryptogenic 20 (10.5%) 13 (15.5%) 7 (6.5%) 0.057
Tumor Characteristics     
Total tumor diameter (mean)+ 5.42 5.81 5.125 0.29
Multinodular 107 (56%) 46 (54.8%) 61 (57%) 0.77
Macrovascular Invasion 27 (14.1%) 17 (20.2%) 10 (9.3%) 0.032
Microvascular Invasion Only 33(17.4%) 15 (17.9%) 18 (17.0%) 0.87
Portal Vein Thrombosis 33 (17.3%) 19 (22.6%) 14 (13.1%) 0.12
Laboratory Parameters++     
MELD score (Mean ± SD) 15.91 ± 7.8 14.69 ± 7.19 16.86 ± 8.27 0.062
INR (Mean ± SD) 1.51 ± 0.52 1.37 ± 0.35 1.64 ± 0.59 0.001
Albumin (Mean ± SD) 3.3 ± 0.73 3.34 ± 0.82 3.27 ± 0.65 0.55
Bilirubin (Mean ± SD) 4.12 ± 5.69 3.34 ± 4.96 4.73 ± 6.16 0.071
Creatinine (Mean ± SD) 1.27 ± 0.81 1.36 ± 0.94 1.21 ± 0.70 0.20
Alpha fetoprotein IU/ml (median) 16.5+++ 16.5 16.5 0.63
Alpha fetoprotein IU/ml (mean)   978 542 0.35
HCC treatment     
Chemoembolization 5(2.6%) 3(3.6%) 2 (1.9%) 0.76
Radiation 11(5.8%) 4 (4.8%) 7 (6.5%) 0.76
Ablation 7 (3.7%) 3 (3.6%) 4 (3.7%) 0.95
Transplant wait list time (mean number of months)   5.9 months 7.5 months 0.43
  1. * Five patients had more than one etiologic risk factor.
  2. + seven missing values.
  3. ++twenty one patients from pre-MELD era were missing laboratory values and MELD score.
  4. +++ two missing values.