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Table 5 Use of optimal boundary values of serum tumor markers for gastric cancer diagnosis

From: Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer

  AFP CEA CA125 CA19-9 Combination
AUC (95% CI) 0.449 0.767 0.589 0.566 0.785
(0.390~ (0.718~ (0.529~ (0.503~ (0.739~
0.509) 0.816) 0.648) 0.630) 0.832)
Positive boundary value ≥7.29 ng/mL ≥2.24 ng/mL ≥22.90 U/mL ≥19.53 U/mL ≥0.419
Sensitivity (%) 4.7 58.4 19.5 30.2 47.7
Specificity (%) 99.1 83.4 95.7 92.8 91.1
Accuracy (%) 62.5 73.7 66.1 68.5 74.2
Positive/negative predictive value (%) 77.8/62.1 69.0/76.0 74.4/65.2 72.6/67.7 77.2/73.3
Positive/Negative likelihood ratio 5.52/0.96 3.52/0.50 4.57/0.84 4.18/0.75 5.33/0.58