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Table 4 Use of normal cut-off values of serum tumor markers for gastric cancer diagnosis

From: Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer

  AFP CEA CA125 CA19-9 Combination
Normal boundary value ≤7 ng/mL ≤6.5 ng/mL ≤35 U/mL ≤27 U/mL -
AUC (95% CI) 0.519 0.583 0.553 0.585 0.667
(0.459~ (0.523~ (0.493~ (0.525~ (0.609~0.726)
0.579) 0.643) 0.614) 0.645)  
Sensitivity (%) 4.7 17.4 14.1 20.8 40.3
Specificity (%) 99.1 99.1 96.6 96.2 93.2
Accuracy (%) 62.5 67.4 64.6 66.9 72.7
Positive/Negative predictive value (%) 77.8/62.1 92.9/65.4 72.4/63.9 77.5/65.7 78.9/71.1
Positive/negative likelihood ratio 5.52/0.96 20.5/0.83 4.14/0.89 5.43/0.82 5.91/0.64