TY - JOUR AU - Kuramoto, Takanori AU - Umegaki, Eiji AU - Nouda, Sadaharu AU - Narabayashi, Ken AU - Kojima, Yuichi AU - Yoda, Yukiko AU - Ishida, Kumi AU - Kawakami, Ken AU - Abe, Yosuke AU - Takeuchi, Toshihisa AU - Inoue, Takuya AU - Murano, Mitsuyuki AU - Tokioka, Satoshi AU - Higuchi, Kazuhide PY - 2013 DA - 2013/05/14 TI - Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study JO - BMC Gastroenterology SP - 85 VL - 13 IS - 1 AB - Proton-pump inhibitors such as omeprazole are a standard treatment to prevent non-steroidal anti-inflammatory drug-induced upper gastrointestinal mucosal injuries. However, it is unclear which drugs may protect against all NSAID-induced digestive-tract injuries. Here, we compare the efficacy of the gastromucoprotective drug irsogladine with omeprazole in preventing NSAID-induced esophagitis, peptic ulcers, and small-intestinal mucosal injury in healthy subjects. SN - 1471-230X UR - https://doi.org/10.1186/1471-230X-13-85 DO - 10.1186/1471-230X-13-85 ID - Kuramoto2013 ER -