From: Evaluation of the Hepa Wash®treatment in pigs with acute liver failure
Time [h] | T0 | T4 | T8 | T12 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Group | Controls (n=5) | Hepa Wash (n=6) | MARS (n=2) | Control (n=5) | Hepa Wash (n=6) | MARS (n=2) | Control (n=5) | Hepa Wash (n=6) | MARS (n=2) | Control (n=2) | Hepa Wash (n=6) |
Blood pH | 7.41±0.02 | 7.42±0.02 | 7.44, 7.41 | 7.35±0.03 | 7.41±0.02 | 7.35, 7.34 | 7.33±0.02 | 7.44±0.02* | 7.36,7.33 | 7.27, 7.30 | 7.42±0.01* |
Sodium [mmol/l] | 136±1 | 136±1 | 133, 136 | 137±1 | 138±2 | 132, 134 | 134±1 | 143±2* | 130, 130 | 138, 133 | 142±2* |
Potassium [mmol/l] | 4.3±0.1 | 4.4±0.2 | 4.9, 4.3 | 4.4±0.2 | 4.5±0.3 | 5.1, 4.23 | 4.8±0.2 | 4.0±0.2 | 4.9, 5.2 | 5.4, 5.7 | 4.4±0.3 |
Glucose [mg/dl] | 98±9 | 112 ± 8 | 95, 107 | 111±14 | 109±10 | 143, 135 | 154±48 | 106±3 | 102, 145 | 120, 127 | 97±6* |
ALP [U/l] | 130±12 | 128 ± 8 | 181, 101 | 199±12 | 187±13 | 277, 136 | 279±12 | 253±11 | 382, 226 | 304, 326 | 323±14 |
GPT [U/l] | 27 ± 2 | 36 ± 2 | 37, 39 | 74 ± 15 | 152 ± 42 | 184, 83 | 111 ± 15 | 213 ± 26* | 201, 226 | 128, 108 | 222 ± 19* |
GOT [U/l] | 29 ± 1 | 33 ± 4 | 17,28 | 962 ± 263 | 2607 ± 884 | 3086, 1179 | 1977 ± 348 | 4076 ± 446* | 3464, 5593 | 2024, 2254 | 4250 ± 282* |
Total protein [g/dl] | 5.4±0.3 | 5.3 ± 0.2 | 5.8, 5.6 | 5.2±0.3 | 5.2±0.1 | 5.2, 5.0 | 4.8±0.4 | 5.2±0.2 | 5.1, 4.9 | 4.3, 3.5 | 4.9±0.3 |
Total Bilirubin [mg/dl] | 0.2±0.0 | 0.2±0.0 | 0.3, 0.2 | 0.6±0.1 | 0.5±0.1 | 0.7, 0.3 | 0.8±0.2 | 0.5±0.1 | 0.9, 0.5 | 1.0, 0.5 | 0.6±0.0 |
BUN [mg/dl] | 9±1 | 9±1 | 11, 11 | 9±1 | 7±1 | 11, 9 | 9±1 | 5±0* | 10, 10 | 8, 9 | 5±0.3* |
Creatinine [mg/dl] | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.3, 1.1 | 1.4 ± 0.1 | 1.2 ± 0.1 | 1.5, 1.2 | 2.2 ± 0.1 | 1.0 ± 0.0* | 2.1, 1.6 | 3.5, 3.5 | 1.3 ± 0.2* |
Ammonia [μg/dl] | 201 ± 31 | 178 ± 18 | 168, 235 | 514 ± 69 | 535 ± 61 | 734, 820 | 977 ± 193 | 454 ± 102 | 1072, 1077 | 1395,1268 | 562 ± 124* |
Lactate [mmol/l] | 2.0±0.1 | 1.6±0.1 | 1.2, 1.2 | 2.5±0.4 | 2.4±0.4 | 2.2, 1.6 | 1.9±0.1 | 1.9±0.2 | 1.5, 1.5 | 2.5, 3.5 | 2.5±0.4 |
INR | 0.9±0.0 | 1.0±0.0 | 0.9, 0.9 | 1.2±0.1 | 1.3±0.1 | 1.1, 1.1 | 2.0±0.5 | 1.7±0.2 | 1.4, 1.9 | 1.7, 1.9 | 2.0±0.1 |
Fibrinogen [mg/dl] | 425±77 | 456±18 | 513, 507 | 393±69 | 348±32 | 377, 372 | 303±71 | 262±21 | 290, 312 | 205,182 | 218±18 |
Hemoglobin [g/dl] | 9.5±0.5 | 8.8±0.4 | 10, 10.4 | 10.1±0.5 | 8.1±0.5 | 9.1, 9.2 | 8.5±0.5 | 7.3±0.4 | 7.1, 8.3 | 7.8, 7.1 | 6.5±0.3 |
Platelets [G/l] | 360±32 | 316±32 | 269, 291 | 279±51 | 196±19 | 180, 201 | 228±31 | 129±6 | 122, 130 | 104, 180 | 117±11 |
Antithrombin III [%] | 65±3 | 70±2 | 83, 78 | 53±3 | 55±4 | 59, 55 | 42±2 | 42±2 | 47, 42 | 30, 31 | 33±1 |
Nitrate/Nitrite [μmol/l] | 25.4±7.6 | 33.5±10.7 | - | 22.8±6.5 | 27.8±7.9 | - | 29.4±8.7 | 7.0±2.0 | - | 33.76, 76.15 | 5.5±1.6 |