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Table 2 List of the main biochemical and hematological parameters of animals in the control and Hepa Wash groups

From: Evaluation of the Hepa Wash®treatment in pigs with acute liver failure

Time [h]

T0

T4

T8

T12

Group

Controls (n=5)

Hepa Wash (n=6)

MARS (n=2)

Control (n=5)

Hepa Wash (n=6)

MARS (n=2)

Control (n=5)

Hepa Wash (n=6)

MARS (n=2)

Control (n=2)

Hepa Wash (n=6)

Blood pH

7.41±0.02

7.42±0.02

7.44, 7.41

7.35±0.03

7.41±0.02

7.35, 7.34

7.33±0.02

7.44±0.02*

7.36,7.33

7.27, 7.30

7.42±0.01*

Sodium [mmol/l]

136±1

136±1

133, 136

137±1

138±2

132, 134

134±1

143±2*

130, 130

138, 133

142±2*

Potassium [mmol/l]

4.3±0.1

4.4±0.2

4.9, 4.3

4.4±0.2

4.5±0.3

5.1, 4.23

4.8±0.2

4.0±0.2

4.9, 5.2

5.4, 5.7

4.4±0.3

Glucose [mg/dl]

98±9

112 ± 8

95, 107

111±14

109±10

143, 135

154±48

106±3

102, 145

120, 127

97±6*

ALP [U/l]

130±12

128 ± 8

181, 101

199±12

187±13

277, 136

279±12

253±11

382, 226

304, 326

323±14

GPT [U/l]

27 ± 2

36 ± 2

37, 39

74 ± 15

152 ± 42

184, 83

111 ± 15

213 ± 26*

201, 226

128, 108

222 ± 19*

GOT [U/l]

29 ± 1

33 ± 4

17,28

962 ± 263

2607 ± 884

3086, 1179

1977 ± 348

4076 ± 446*

3464, 5593

2024, 2254

4250 ± 282*

Total protein [g/dl]

5.4±0.3

5.3 ± 0.2

5.8, 5.6

5.2±0.3

5.2±0.1

5.2, 5.0

4.8±0.4

5.2±0.2

5.1, 4.9

4.3, 3.5

4.9±0.3

Total Bilirubin [mg/dl]

0.2±0.0

0.2±0.0

0.3, 0.2

0.6±0.1

0.5±0.1

0.7, 0.3

0.8±0.2

0.5±0.1

0.9, 0.5

1.0, 0.5

0.6±0.0

BUN [mg/dl]

9±1

9±1

11, 11

9±1

7±1

11, 9

9±1

5±0*

10, 10

8, 9

5±0.3*

Creatinine [mg/dl]

1.3 ± 0.1

1.3 ± 0.1

1.3, 1.1

1.4 ± 0.1

1.2 ± 0.1

1.5, 1.2

2.2 ± 0.1

1.0 ± 0.0*

2.1, 1.6

3.5, 3.5

1.3 ± 0.2*

Ammonia [μg/dl]

201 ± 31

178 ± 18

168, 235

514 ± 69

535 ± 61

734, 820

977 ± 193

454 ± 102

1072, 1077

1395,1268

562 ± 124*

Lactate [mmol/l]

2.0±0.1

1.6±0.1

1.2, 1.2

2.5±0.4

2.4±0.4

2.2, 1.6

1.9±0.1

1.9±0.2

1.5, 1.5

2.5, 3.5

2.5±0.4

INR

0.9±0.0

1.0±0.0

0.9, 0.9

1.2±0.1

1.3±0.1

1.1, 1.1

2.0±0.5

1.7±0.2

1.4, 1.9

1.7, 1.9

2.0±0.1

Fibrinogen [mg/dl]

425±77

456±18

513, 507

393±69

348±32

377, 372

303±71

262±21

290, 312

205,182

218±18

Hemoglobin [g/dl]

9.5±0.5

8.8±0.4

10, 10.4

10.1±0.5

8.1±0.5

9.1, 9.2

8.5±0.5

7.3±0.4

7.1, 8.3

7.8, 7.1

6.5±0.3

Platelets [G/l]

360±32

316±32

269, 291

279±51

196±19

180, 201

228±31

129±6

122, 130

104, 180

117±11

Antithrombin III [%]

65±3

70±2

83, 78

53±3

55±4

59, 55

42±2

42±2

47, 42

30, 31

33±1

Nitrate/Nitrite [μmol/l]

25.4±7.6

33.5±10.7

-

22.8±6.5

27.8±7.9

-

29.4±8.7

7.0±2.0

-

33.76, 76.15

5.5±1.6

  1. BUN: blood urea nitrogen. ALP: alkaline phosphatase.*p<0.05 (difference between Hepa Wash and control).