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Table 2 List of the main biochemical and hematological parameters of animals in the control and Hepa Wash groups

From: Evaluation of the Hepa Wash®treatment in pigs with acute liver failure

Time [h] T0 T4 T8 T12
Group Controls (n=5) Hepa Wash (n=6) MARS (n=2) Control (n=5) Hepa Wash (n=6) MARS (n=2) Control (n=5) Hepa Wash (n=6) MARS (n=2) Control (n=2) Hepa Wash (n=6)
Blood pH 7.41±0.02 7.42±0.02 7.44, 7.41 7.35±0.03 7.41±0.02 7.35, 7.34 7.33±0.02 7.44±0.02* 7.36,7.33 7.27, 7.30 7.42±0.01*
Sodium [mmol/l] 136±1 136±1 133, 136 137±1 138±2 132, 134 134±1 143±2* 130, 130 138, 133 142±2*
Potassium [mmol/l] 4.3±0.1 4.4±0.2 4.9, 4.3 4.4±0.2 4.5±0.3 5.1, 4.23 4.8±0.2 4.0±0.2 4.9, 5.2 5.4, 5.7 4.4±0.3
Glucose [mg/dl] 98±9 112 ± 8 95, 107 111±14 109±10 143, 135 154±48 106±3 102, 145 120, 127 97±6*
ALP [U/l] 130±12 128 ± 8 181, 101 199±12 187±13 277, 136 279±12 253±11 382, 226 304, 326 323±14
GPT [U/l] 27 ± 2 36 ± 2 37, 39 74 ± 15 152 ± 42 184, 83 111 ± 15 213 ± 26* 201, 226 128, 108 222 ± 19*
GOT [U/l] 29 ± 1 33 ± 4 17,28 962 ± 263 2607 ± 884 3086, 1179 1977 ± 348 4076 ± 446* 3464, 5593 2024, 2254 4250 ± 282*
Total protein [g/dl] 5.4±0.3 5.3 ± 0.2 5.8, 5.6 5.2±0.3 5.2±0.1 5.2, 5.0 4.8±0.4 5.2±0.2 5.1, 4.9 4.3, 3.5 4.9±0.3
Total Bilirubin [mg/dl] 0.2±0.0 0.2±0.0 0.3, 0.2 0.6±0.1 0.5±0.1 0.7, 0.3 0.8±0.2 0.5±0.1 0.9, 0.5 1.0, 0.5 0.6±0.0
BUN [mg/dl] 9±1 9±1 11, 11 9±1 7±1 11, 9 9±1 5±0* 10, 10 8, 9 5±0.3*
Creatinine [mg/dl] 1.3 ± 0.1 1.3 ± 0.1 1.3, 1.1 1.4 ± 0.1 1.2 ± 0.1 1.5, 1.2 2.2 ± 0.1 1.0 ± 0.0* 2.1, 1.6 3.5, 3.5 1.3 ± 0.2*
Ammonia [μg/dl] 201 ± 31 178 ± 18 168, 235 514 ± 69 535 ± 61 734, 820 977 ± 193 454 ± 102 1072, 1077 1395,1268 562 ± 124*
Lactate [mmol/l] 2.0±0.1 1.6±0.1 1.2, 1.2 2.5±0.4 2.4±0.4 2.2, 1.6 1.9±0.1 1.9±0.2 1.5, 1.5 2.5, 3.5 2.5±0.4
INR 0.9±0.0 1.0±0.0 0.9, 0.9 1.2±0.1 1.3±0.1 1.1, 1.1 2.0±0.5 1.7±0.2 1.4, 1.9 1.7, 1.9 2.0±0.1
Fibrinogen [mg/dl] 425±77 456±18 513, 507 393±69 348±32 377, 372 303±71 262±21 290, 312 205,182 218±18
Hemoglobin [g/dl] 9.5±0.5 8.8±0.4 10, 10.4 10.1±0.5 8.1±0.5 9.1, 9.2 8.5±0.5 7.3±0.4 7.1, 8.3 7.8, 7.1 6.5±0.3
Platelets [G/l] 360±32 316±32 269, 291 279±51 196±19 180, 201 228±31 129±6 122, 130 104, 180 117±11
Antithrombin III [%] 65±3 70±2 83, 78 53±3 55±4 59, 55 42±2 42±2 47, 42 30, 31 33±1
Nitrate/Nitrite [μmol/l] 25.4±7.6 33.5±10.7 - 22.8±6.5 27.8±7.9 - 29.4±8.7 7.0±2.0 - 33.76, 76.15 5.5±1.6
  1. BUN: blood urea nitrogen. ALP: alkaline phosphatase.*p<0.05 (difference between Hepa Wash and control).