Figure 3

Effect of corilagin on pathological manifestation of hepatic tissue at 48h. A: Corilagin group; B: UDCA group; C: Dexamethasone group; D: Model group; E: Normal group. In normal group, hepatic tissue showed intact hepatic lobules, orderly liver cell cord, hepatic cell with uniform stain, epithelial cells of bile duct without damage, and no infiltration of neutrophilic granulocyte. In model group, the liver tissue showed typical pathological changes. At 48h, the liver cells showed more significantly swelling, cytoplasm with puff, ununiformed nucleus with accumulative chromatin and enlarged, strong-stained nucleolus. The liver tissue showed plenty of punctiform or focused necrotic zones and proliferation of Kupffer cells and bile duct epithelial cells all over the visual field. The bile duct exhibited a constrictive canal with necrotic cells and bile thrombus. Many necrotic hepatocytes and infiltrated neutrophils were present around the bile duct. In the corilagin group the pathological changes were significantly lower than in the model group. The manifestations in the UDCA group were a little severer than in the corilagin group while in the dexamethasone group the pathological impairment appeared more aggravated.