Effect of NOD2 variants on underweight, growth failure, short stature and hospitalization in pediatric-onset CD patients. Pediatric-onset CD patients with NOD2 variant (grey bars) or NOD2 wild-type alleles (white bars) were compared regarding underweight at diagnosis and during follow up, growth failure, short stature and hospitalization for more than two weeks per year. BMI at diagnosis and growth delay at one-year follow-up was available from 51 out of 85 patients (39% NOD2 variant allele carriers). Differences were compared using chi-square or Fishers exact test, respectively. A p-value below ≤0.05 was considered to be significant.