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Table 2 Comparison of non-amino acid metabolite levels between the control and ALF groups

From: Metabonomic analysis of liver tissue from BALB/c mice with d-galactosamine/lipopolysaccharide-induced acute hepatic failure

No. Retention Time Metabolites Control Group ALF Group Ratioa P
16 6.02 lactate 238.84 ± 36.26 233.85 ± 38.91 0.98 0.8318
17 7.88 ethanedioic acid 5.92 ± 2.28 4.06 ± 1.51 0.69 0.1749
18 8.39 β-hydroxybutyrate 17.43 ± 1.96 5.09 ± 1.95 0.29 0.0017
19 10.91 urea 43.17 ± 6.07 20.54 ± 2.04 0.48 0.0013
20 11.20 phosphate 61.90 ± 10.34 38.67 ± 8.61 0.62 0.0279
21 11.30 glycerol 502.25 ± 42.61 459.58 ± 41.69 0.92 0.1886
22 12.35 succinic acid 30.58 ± 2.72 3.76 ± 1.68 0.12 0.0000
23 12.90 uracil 26.65 ± 5.82 29.78 ± 8.73 1.12 0.6393
24 13.31 fumaric acid 12.96 ± 3.60 11.67 ± 4.08 0.90 0.6120
25 13.78 pyruvate acid 8.46 ± 1.62 8.75 ± 0.96 1.03 0.7939
26 16.76 malic acid 45.24 ± 8.33 48.72 ± 4.17 1.08 0.4257
27 17.70 4-amino-butanoic acid 29.14 ± 3.50 33.28 ± 9.01 1.14 0.4762
28 18.50 erythronic acid 3.06 ± 0.77 1.01 ± 0.32 0.33 0.0064
29 19.28 2-piperidinedicarboxylic acid 19.73 ± 6.01 13.73 ± 5.56 0.70 0.0985
30 21.20 2,3,4-trihydroxy-butanal 99.30 ± 10.48 52.41 ± 12.11 0.53 0.0021
31 23.07 phosphoglyceride 114.73 ± 29.17 31.67 ± 9.72 0.28 0.0014
32 23.43 2-(bisamino)ethyl-phosphoric acid 48.32 ± 7.80 44.76 ± 9.20 0.93 0.3720
33 23.86 hypoxanthine 96.71 ± 15.64 62.57 ± 7.83 0.65 0.0425
34 24.26 arabinonic acid 1.66 ± 0.59 36.94 ± 5.53 22.25 0.0003
35 24.90 tetradecoic acid 74.92 ± 7.62 49.23 ± 8.42 0.66 0.0058
36 25.33 fructose 5.97 ± 1.30 3.19 ± 0.85 0.53 0.0092
37 25.63 glucose 439.00 ± 67.12 360.72 ± 42.74 0.82 0.0450
38 25.72 mannose 64.66 ± 14.56 37.53 ± 12.48 0.58 0.0137
39 26.22 galactose 158.06 ± 41.44 123.44 ± 19.37 0.78 0.0703
40 27.13 gluconic acid 66.74 ± 12.23 11.59 ± 4.73 0.17 0.0002
41 27.55 glucopyranose 98.84 ± 37.07 73.62 ± 27.60 0.74 0.3248
42 27.69 pantothenic acid 2.61 ± 1.12 2.47 ± 1.36 0.95 0.8489
43 28.18 purine 72.29 ± 18.01 35.07 ± 5.22 0.49 0.0180
44 28.48 6-deoxy-mannose 28.08 ± 7.66 10.19 ± 2.39 0.36 0.0052
45 28.84 palmitic acid 154.73 ± 16.61 162.99 ± 6.64 1.05 0.4927
46 29.54 inositol 85.87 ± 1.51 83.94 ± 6.01 0.98 0.5510
47 30.44 sedoheptulose 20.10 ± 7.80 3.07 ± 1.40 0.15 0.0121
48 31.82 linoleic acid 155.45 ± 17.62 144.69 ± 10.84 0.93 0.3358
49 31.93 oleic acid 116.51 ± 15.37 105.46 ± 7.70 0.91 0.3304
50 32.40 stearic acid 79.60 ± 5.93 83.70 ± 2.35 1.05 0.2288
51 33.63 glucopyranose phosphate 4.34 ± 1.76 2.36 ± 0.77 0.54 0.0538
52 32.44 arachidonic acid 62.30 ± 9.64 41.11 ± 8.21 0.66 0.0103
53 35.07 inositol monophosphate 5.50 ± 0.76 2.66 ± 0.70 0.48 0.0030
54 37.31 fructose phosphate 13.23 ± 4.61 0.50 ± 0.20 0.04 0.0061
55 37.44 ducosahexenoic acid 37.45 ± 5.03 37.42 ± 14.06 1.00 0.9963
56 37.70 adenosine 197.33 ± 36.90 29.66 ± 9.87 0.15 0.0008
57 40.15 maltose 41.62 ± 11.28 80.62 ± 27.90 1.94 0.0390
58 45.60 cholesterol 66.99 ± 11.90 35.54 ± 8.76 0.53 0.0330
  1. aMeans ratio of metabolite levels between ALF and control groups.