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Table 1 Comparison of liver amino acid levels between the control and ALF groups

From: Metabonomic analysis of liver tissue from BALB/c mice with d-galactosamine/lipopolysaccharide-induced acute hepatic failure

No.

Retention Time

Amino Acids

Control Group

ALF Group

Ratioc

P

1

6.98

alanine

197.63 ± 25.91

162.54 ± 23.76

0.82

0.0889

2

9.87

valine

81.52 ± 9.32

79.34 ± 13.53

0.97

0.8230

3

11.78

isoleucine

41.67 ± 8.16

43.00 ± 5.56

1.03

0.8026

4

11.86

5-oxy-proline

44.91 ± 11.28

50.17 ± 6.79

1.12

0.5499

5

12.10

glycine

157.18 ± 18.62

120.83 ± 11.80

0.77

0.0208

6

13.53

serine

98.42 ± 7.32

100.49 ± 9.06

1.02

0.7926

7

14.15

threonine

88.84 ± 10.42

77.97 ± 7.22

0.88

0.1624

8

15.20

B-alanine

38.87 ± 9.79

19.36 ± 1.63

0.50

0.0182

9

17.43

proline

99.95 ± 17.81

74.37 ± 7.51

0.74

0.0472

10

17.53

aspartate

54.20 ± 11.68

50.40 ± 4.85

0.93

0.6024

11

19.90

glutamate

98.41 ± 15.86

77.18 ± 5.01

0.78

0.0491

12

20.98

asparagine

2.06 ± 0.81

2.60 ± 0.78

1.26

0.5246

13

24.18

ornithine

41.78 ± 10.86

67.31 ± 14.79

1.61

0.1087

14

25.57

tyrosine

67.81 ± 9.84

32.34 ± 9.02

0.48

0.0008

15

26.37

lysine

10.61 ± 1.61

64.29 ± 12.27

6.06

0.0008

  

TAAa

1123.87 ± 115.19

1022.21 ± 113.20

0.91

0.2207

  

Gluconeogenic amino acidsb

1003.66 ± 118.93

858.26 ± 85.36

0.86

0.0656

  1. a Total amino acids. bGluconeogenic amino acids include aspartate, serine, glycine, threonine, alanine, proline, lysine, tyrosine, valine, and isoleucine. cMeans ratio of metabolite levels between ALF and control groups.