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Table 2 Comparison of various methods for diagnosing H. pylori infection in children with gastritis, using gold standard (GS) or mucosal florescent quantitative PCR (mfqPCR) as the reference

From: Evaluation of a new fluorescence quantitative PCR test for diagnosing Helicobacter pylori infection in children

  Routine histology RUT 13C-UBT Gastric fluid PCR Dental plaque PCR
Standard GS mfqPCR GS mfqPCR GS mfqPCR GS mfqPCR GS mfqPCR
Sensitivity % 92.1 76.1 92.1 76.1 81.6 60.9 84.2 69.6 78.9 65.2
Specificity % 100.0 100.0 90.0 89.1 97.0 96.7 100.0 100.0 100.0 100.0
PPV % 100.0 100.0 77.8 77. 8 90.3 90.3 100.0 100.0 100.0 100.0
NPV % 97.1 89.3 96.8 88.2 90.1 83.2 94.3 86.8 92.6 85.2
  1. PPV: positive predictive value; NPV: negative predictive value; RUT: rapid urease test; 13C-UBT, urea breath test.