Table 3 Relative risk of 30-day mortality after colorectal cancer surgery in subgroups of patients with liver disease
Subgroups | Patients N | No liver disease (reference cohort) | Non-cirrhotic liver disease Adjusted* RR (95%CI) | Liver cirrhosis Adjusted* RR (95%CI) |
|---|---|---|---|---|
Gender: | Â | Â | Â | Â |
- Male | 20,390 | 1.00 (ref) | 1.37 (0.88-2.13) | 2.21 (1.20-4.01) |
- Female | 19,450 | 1.00 (ref) | 1.56 (1.08-2.26) | 2.82 (1.90-4.20) |
Age at colorectal surgery (years): | Â | Â | Â | Â |
- 0-59 | 7,160 | 1.00 (ref) | 2.71 (1.25-5.89) | 3.53 (1.53-8.13) |
- 60-69 | 10,254 | 1.00 (ref) | 1.56 (0.83-2.95) | 3.61 (2.00-6.52) |
- 70-79 | 13,332 | 1.00 (ref) | 1.10 (0.65-1.87) | 2.37 (1.40-4.02) |
- 80+ | 9,094 | 1.00 (ref) | 1.61 (1.01-2.56) | 1.14 (0.36-3.59) |
Timing of admission: | Â | Â | Â | Â |
- Acute | 12,829 | 1.00 (ref) | 1.57 (1.11-2.22) | 2.48 (1.59-3.88) |
- Elective | 26,932 | 1.00 (ref) | 1.39 (0.85-2.28) | 2.79 (1.70-4.57) |
Cancer stage: | Â | Â | Â | Â |
- Localized | 17,272 | 1.00 (ref) | 1.16 (0.65-2.06) | 3.49 (2.06-5.93) |
- Non-localized | 19,121 | 1.00 (ref) | 1.71 (1.20-2.43) | 2.42 (1.49-3.94) |
- Stage unknown | 3,447 | 1.00 (ref) | 1.41 (0.58-3.42) | 2.24 (0.91-5.50) |
Surgery: | Â | Â | Â | Â |
- Laparoscopic radical resection | 3,528 | 1.00 (ref) | NA | 6.82 (1.48-31.45) |
- Open radical resection | 31,693 | 1.00 (ref) | 1.41 (0.99-1.98) | 3.01 (2.05-4.40) |
- Non-resectional procedures | 4,619 | 1.00 (ref) | 1.91 (1.14-3.20) | 1.74 (0.82-3.67) |
Comorbidity level: | Â | Â | Â | Â |
- Low | 24,528 | 1.00 (ref) | 1.62 (0.97-2.70) | 3.41 (1.97-5.91) |
- Moderate | 11,783 | 1.00 (ref) | 1.60 (1.07-2.41) | 3.14 (1.91-5.16) |
- High | 3,529 | 1.00 (ref) | 1.17 (0.62-2.19) | 1.47 (0.68-3.15) |
Non-hepatic alcohol-related disease †: |  |  |  |  |
- Yes | 682 | 1.00 (ref) | 1.30 (0.94-1.81) | 3.37 (2.30-4.92) |
- No | 39,158 | 1.00 (ref) | 2.61 (1.43-4.76) | 1.67 (0.88-3.10) |