Esomeprazole 20 mg once daily | |||
---|---|---|---|
0–24 weeks (n=130) | 24–52 weeks (n=116) | 0–52 weeks (n=130) | |
Any AEa | 105 (80.8) | 93 (80.2) | 123 (94.6) |
Nasopharyngitis | 26 (20.0) | 22 (19.0) | 38 (29.2) |
Rheumatoid arthritis aggravated | 13 (10.0) | 4 (3.4) | 17 (13.1) |
Upper abdominal pain | 8 (6.2) | 8 (6.9) | 14 (10.8) |
Constipation | 7 (5.4) | 5 (4.3) | 12 (9.2) |
Diarrhoea | 6 (4.6) | 5 (4.3) | 11 (8.5) |
Stomach discomfort | 6 (4.6) | 4 (3.4) | 10 (7.7) |
Osteoarthritis | 4 (3.1) | 5 (4.3) | 9 (6.9) |
Headache | 6 (4.6) | 2 (1.7) | 8 (6.2) |
Nausea | 0 | 8 (6.9) | 8 (6.2) |
Anorexia | 3 (2.3) | 4 (3.4) | 7 (5.4) |
Arthralgia | 3 (2.3) | 4 (3.4) | 7 (5.4) |
Contusion | 4 (3.1) | 4 (3.4) | 7 (5.4) |
Hypertension | 4 (3.1) | 3 (2.6) | 7 (5.4) |
Stomatitis | 2 (1.5) | 5 (4.3) | 7 (5.4) |
Vomiting | 3 (2.3) | 4 (3.4) | 7 (5.4) |
Severe AEs | 2 (1.5) | 1 (0.9) | 3 (2.3) |
Non-fatal serious AEs | 13 (10.0) | 5 (3.8) | 18 (13.8) |
AEs leading to treatment discontinuationb | 5 (3.8) | 1 (0.9) | 6 (4.6) |