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Table 3 Predictors of rods and rings antibody (RR) positivity

From: Clinical associations and potential novel antigenic targets of autoantibodies directed against rods and rings in chronic hepatitis C infection

Characteristic

RR negative (n=300)

RR positive (n=15)

P-value

Demographics

   

 Median age, yrs

51 (44–54)

51 (46–61)

0.38

 Male gender

61% (182)

73% (11)

0.42

HCV genotype 1

76% (228)

73% (11)

0.76

Prior injection drug use

45% (134)

47% (7)

1.00

Prior HCV treatment

3% (9)

33% (5)

<0.0005

Biochemical data †

   

 ALT, IU/L

65 (42–110)

52 (24–80)

0.16

 Platelets, x109/L

202 (167–243)

182 (134–245)

0.38

Histologic characteristics

   

 A2-3 necroinflammation

73% (218)

53% (8)

0.14

 F2-4 fibrosis

66% (198)

67% (10)

1.00

Autoantibodies

   

 ANA positive

89% (266)

100% (15)

0.39

 AMA positive

2% (5)

0% (0)

1.00

  1. Abbreviations: ANA, antinuclear antibodies; AMA, anti-mitochondrial antibodies; RR, Rods and Rings. † ALT and platelets missing in 10 and 5 patients, respectively.