Clinical associations and potential novel antigenic targets of autoantibodies directed against rods and rings in chronic hepatitis C infection

Table 2 Potential RR autoantibody targets indentified on a protein/peptide microarray

Clone ID	Description	Structure/function	Reactivity*
MPMGp800M18568 MPMGp800E06542 MPMGp800H07541 MPMGp800P08580	Homo sapiens MAZI; Alternate name: Purine- binding transcription factor (ZF87) (ZIF87). Source: SWISSPROT; Acc:P56270	C2H2-type zinc fingers; transcription initiation and termination; purine metabolism [39, 40]	4+
MPMGp800O22578	Homo sapiens VDAC1	Outer mitochondrial membrane; role in apoptosis and cancer; interacts with amyloid and tau role in Alzheimer’s [41–43]	3+
MPMGp800A24548	Homo sapiens ARM and sterile alpha motif domain containing 6 (ANKS6)	ARM participate in protein folding and found in ~6% of eukaryotic proteins [44, 45]	2+
MPMGp800L08582	Homo sapiens ARP1 – homolog A (ACTR1A)	Major subunit of dynactin; molecular motor component; binds ATP and NuMA [46, 47]	3+
MPMGp800K12532 MPMGp800L22599 MPMGp800E04593	Unknown proteins	Unknown	2 – 3+

*Reactivity = the intensity of immunoreactivity with proteins on the microarray which were graded from 0 (no reactivity) to 4 (high intensity).
Abbreviations: ARM, ankyrin repeat motif; ARP, actin-related protein; ATP, adenosine triphospate; MAZI, Myc-associated zinc finger protein; NuMA, nuclear mitotic apparatus (NuMA) protein; VDAC1, voltage-dependent anion channel 1.

ISSN: 1471-230X