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Table 1 Baseline characteristics

From: Attenuated antigen-specific T cell responses in cirrhosis are accompanied by elevated serum interleukin-10 levels and down-regulation of HLA-DR on monocytes

Characteristic Controls (N=14) Patients with cirrhosis without inflammation (N = 13) Patients with cirrhosis and inflammation (N = 22) P value
Years of age – median (range) 39 (22–52) 55 (37–81) 65 (44–82) <0.001
Male sex – no. (%) 8 (57%) 7 (54%) 14 (64%) n.s.
Positive Epstein-Barr virus serology – no. (%) 12/14 (85%) 11/11 (100%) 25/25 (100%) n.s.
LBP serum concentration (μg/ml) – median (range) 14 (7–22) 30 (12–44) 33 (10–50) 0.002
IL-10 serum concentration (pg/ml) – median (range) 4 (3–7) 10 (6–37) 14 (7–51) <0.001
Alcoholic aetiology of cirrhosis – no. (%)   8 (62%) 15 (68%) n.s.
Child-Pugh stage A/B/C – no. 6/4/3 2/3/17* 0.005
Child-Pugh score – median (range) 7 (5–13) 10 (6–13)* 0.005
Ascites – no. (%) 5 (38%) 19 (86%)* 0.007
MELD score – median (range) 12 (6–24) 16 (7–33) n.s
Laboratory values - median (range)    
Total serum bilirubin - μmol/l 31 (5–504) 49 (7–324) n.s
International normalized ratio 1.2 (0.9–2.0) 1.4 (1.1–2.2)* 0.029
Creatinine - μmol/l 76 (50–129) 91 (52–235) n.s
Aspartate aminotransferase - μmol/l×s 0.78 (0.46–4.16) 1.23 (0.30–3.42) n.s
Alanine aminotransferase - μmol/l×s 0.77 (0.36–2.68) 0.61 (0.24–1.10) n.s
White blood cell count – Gpt/l 5.8 (2.4–7.2) 6.6 (3.6–16.8)* 0.034
C-reactive protein – mg/l 4.9 (2.0–10.0) 25.5 (12.6–91.9)* <0.001
Serum Albumin – g/l 31 (19–40) 27 (17–35) n.s.
  1. P values in Kruskal-Wallis test or Mann–Whitney U test for continuous data or Fisher’s exact test for discrete data are indicated. * indicates a statistical significant difference between cirrhotic patients with and without elevated C-reactive protein levels.
  2. MELD: Model for end-stage liver disease score, n.s.: not significant (P≥0.05).