Table 3 Comparison of EGF genotype frequencies in HCC patients with control subjects among non-Asians in Los Angeles, California, and Chinese in southern Guangxi, China
Subgroup | EGF 61A > G | Non-Asians in Los Angeles | Chinese in southern Guangxi | ||||
|---|---|---|---|---|---|---|---|
Ca/Co* | OR (95% CI)† | OR (95% CI)‡ | Ca/Co* | OR (95% CI)† | OR (95% CI)‡ | ||
All subjects | A/A | 28/60 | 1.00 | 1.00 | 126/118 | 1.00 | 1.00 |
A/G | 61/102 | 1.61 (0.89–2.90) | 2.04 (1.03–4.07) | 99/107 | 0.87 (0.60–1.26) | 0.69 (0.41–1.18) | |
G/G | 28/63 | 1.34 (0.68–2.64) | 1.39 (0.64–3.01) | 25/20 | 1.17 (0.62–2.22) | 0.97 (0.38–2.46) | |
A/G + G/G | 89/165 | 1.52 (0.87–2.65) | 1.78 (0.93–3.38) | 124/127 | 0.91 (0.64–1.30) | 0.73 (0.44–1.21) | |
Seronegative for all viral hepatitis markers | A/A | 12/52 | 1.00 | 1.00 | 26/101 | 1.00 | 1.00 |
A/G + G/G | 42/146 | 1.65 (0.76–3.55) | 1.95 (0.86–4.41) | 19/109 | 0.65 (0.33–1.27) | 0.61 (0.30–1.23) | |
Seropositive for any viral hepatitis markers§ | A/A | 16/8 | 1.00 | 1.00 | 100/17 | 1.00 | 1.00 |
A/G + G/G | 47/19 | 1.43 (0.50–4.07) | 1.62 (0.50–5.27) | 105/18 | 0.91 (0.44–1.88) | 0.88 (0.41–1.87) | |
Non-drinkers or <3 drinks of alcoholic beverages per day | A/A | 16/45 | 1.00 | 1.00 | 114/115 | 1.00 | 1.00 |
A/G + G/G | 47/139 | 1.12 (0.56–2.23) | 1.60 (0.72–3.52) | 104/121 | 0.86 (0.60–1.25) | 0.75 (0.45–1.26) | |
3+ drinks of alcoholic beverages per day | A/A | 12/15 | 1.00 | 1.00 | 12/3 | 1.00 | 1.00 |
A/G + G/G | 42/26 | 4.34 (1.37–13.74) | 3.44 (0.93–12.76) | 20/6 | 0.74 (0.12–4.70) | 0.32 (0.02–4.83) | |
Non-smokers or long-term ex-smokers¶ | A/A | 17/40 | 1.00 | 1.00 | 71/78 | 1.00 | 1.00 |
A/G + G/G | 53/122 | 1.55 (0.75–3.21) | 1.86 (0.83–4.18) | 70/83 | 0.92 (0.58–1.45) | 0.83 (0.44–1.57) | |
Current smokers or recent ex-smokers¶ | A/A | 11/20 | 1.00 | 1.00 | 55/40 | 1.00 | 1.00 |
A/G + G/G | 36/43 | 1.59 (0.63–3.99) | 1.52 (0.50–4.63) | 54/44 | 0.87 (0.49–1.54) | 0.51 (0.21–1.23) | |