Skip to main content

Table 3 Mean values of mRNA transcript expression in ileal mucosa of important transcription factors in gallstone carriers and healthy controls

From: Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease

  Transcripts/10 ng mRNA
  Total Normal weight Overweight
Group Controls Gallstone carriers Controls Gallstone carriers Controls Gallstone carriers
Target (Mean ± SEM) (n = 95) (n = 29) (n = 55) (n = 9) (n = 40) (n = 20)
LXRα 70261 ± 4308 70004 ± 6774 75035 ± 6026 63318 ± 12203 63853 ± 5964 73544 ± 8245
LXRβ 36208 ± 2570 37337 ± 5445 39285 ± 3445 30067 ± 6295 32361 ± 3821 40781 ± 7426
HNF1α 5282 ± 362 7037 ± 864 5555 ± 488 5814 ± 953 4944 ± 542 7616 ± 1183 a
HNF4α 48814 ± 3407 53086 ± 10701 51632 ± 4561 45244 ± 9990 44939 ± 5115 56615 ± 14955
PPARδ 7326 ± 574 7985 ± 999 7540 ± 806 6821 ± 1468 7060 ± 817 8537 ± 1304
SREBP2 29807 ± 2223 30681 ± 3864 31373 ± 3068 30677 ± 5749 27928 ± 3236 30683 ± 5145
  1. Values are given as means ± SEM (standard error of the mean). Significance between the controls and gallstone carriers was analysed with Mann–Whitney U test (nonparametric, two-tailed). P-values <0.05 were considered as statistical significant.
  2. LXR = liver X receptors, HNF = hepatocyte nuclear factor, PPAR = peroxisome proliferator-activated receptor, SREBP = sterol regulatory element-binding protein.
  3. α P = 0.0470 after adjustment (factor 6) P = 0.282.