BMC Gastroenterology

Table 3 Mean values of mRNA transcript expression in ileal mucosa of important transcription factors in gallstone carriers and healthy controls

From: Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease

	Transcripts/10 ng mRNA
	Total		Normal weight		Overweight
Group	Controls	Gallstone carriers	Controls	Gallstone carriers	Controls	Gallstone carriers
Target (Mean ± SEM)	(n = 95)	(n = 29)	(n = 55)	(n = 9)	(n = 40)	(n = 20)
LXRα	70261 ± 4308	70004 ± 6774	75035 ± 6026	63318 ± 12203	63853 ± 5964	73544 ± 8245
LXRβ	36208 ± 2570	37337 ± 5445	39285 ± 3445	30067 ± 6295	32361 ± 3821	40781 ± 7426
HNF1α	5282 ± 362	7037 ± 864	5555 ± 488	5814 ± 953	4944 ± 542	7616 ± 1183 ^a
HNF4α	48814 ± 3407	53086 ± 10701	51632 ± 4561	45244 ± 9990	44939 ± 5115	56615 ± 14955
PPARδ	7326 ± 574	7985 ± 999	7540 ± 806	6821 ± 1468	7060 ± 817	8537 ± 1304
SREBP2	29807 ± 2223	30681 ± 3864	31373 ± 3068	30677 ± 5749	27928 ± 3236	30683 ± 5145

Values are given as means ± SEM (standard error of the mean). Significance between the controls and gallstone carriers was analysed with Mann–Whitney U test (nonparametric, two-tailed). P-values <0.05 were considered as statistical significant.
LXR = liver X receptors, HNF = hepatocyte nuclear factor, PPAR = peroxisome proliferator-activated receptor, SREBP = sterol regulatory element-binding protein.
^α P = 0.0470 after adjustment (factor 6) P = 0.282.

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